Spotlight: Ketamine Assisted Therapy Outcomes for First-Responders with Comorbid Mental Health Diagnoses (Tsang, et al, 2025)
"KAT may provide meaningful benefits beyond symptom reduction."
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Spotlight: How Ketamine Acts on the Brain - Microtubules & An Orch-Or Perspective
Ketamine has a psychedelic effect and an anesthetic modulation of brain microtubules. How this mechanism works, according to the principles of the Orchestrated Objective Reduction, shared by the Penrose-Hameroff (Orch-OR) consciousness model.
Spotlight: Ketamine Integration Chaplaincy: A Novel Spiritual Care Approach to Psychedelic Integration (2025)
"Although ketamine's mode of action is distinct from classic psychedelics, patients frequently report similar alterations in consciousness, including experiences described as spiritual or religious"
Spotlight: Jeffrey Becker - The Neurobiology Underlying Transcendence Induced by Ketamine and the Psychedelics (2026)
While psychedelics selectively amplify activity in specific neural circuits, ketamine acts on a receptor found widely throughout the brain. This raises a key question: how can a drug targeting such a common receptor produce such distinct and powerful subjective effects?
Spotlight: Yale presents “New Insights into the Neural Mechanisms of NMDA Receptor Antagonists Driving Rapid-Acting Antidepressant Effects” (Cichon, 2026)
"ketamine works on depression within minutes of infusion, lasting multiple days, if not weeks... amazing that it was classified as an anesthetic... twice as good as SSRI standards of care... leads to new formation of synapse, underlying sustaining mechanisms..."
Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells (Korkmaz, et al, 2026)
"findings suggest that ketamine exhibits potential anti-proliferative and pro-apoptotic effects on HT-29 colorectal cancer cells in vitro."
Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)
DMT compared with ketamine variant, esketamine in mice.