Michael DeMarco, PhD

Spotlight: Ketamine Research Lit Review (2022-Current)

Curated on the Fediverse using Mastodon

23 Jul

Spotlight: Therapeutic Ketamine

Getting the most out of your prescription ketamine

22 Jul

Spotlight: Addressing the Gap: Real-World Evidence of Technology-Enabled Coaching Services for Mental Health (2025)

By redefining care and leveraging technology, coaching may be a scalable treatment solution.

19 Jul

Spotlight: "Telehealth-supported ketamine for depression and anxiety: A systematic review (2026)

"Telehealth-supported sublingual racemic ketamine was associated with symptom improvements in selected populations"

15 Jul

Spotlight: NRx Pharmaceuticals Notes Presentation Of IV Ketamine Efficacy Versus Nasal Esketamine Efficacy At American Society Of Clinical Psychopharmacology (2026)

"The authors concluded that in routine clinical care, both IV ketamine and intranasal esketamine rapidly improve depression symptoms with IV ketamine showing higher remission and response rates than intranasal esketamine."

15 Jul

Spotlight: HHS & VA Announce Bold, Comprehensive Partnership to Advance Rapid-Acting Mental Health Treatments for Veterans

Health & Human Services & The Veterans Administration join the Food and Drug Administration in new announcements surrounding psychedelics for mental health

13 Jul

Spotlight: Psychedelic Drugs: Considerations for Clinical Investigations Guidance for Industry

American government agency, the Food and Drug Administration (FDA) releases nonbinding recommendations to psychedelic drug manufacturers

13 Jul

ketamine

Spotlight: Jeffrey Becker - The Neurobiology Underlying Transcendence Induced by Ketamine and the Psychedelics (2026)

While psychedelics selectively amplify activity in specific neural circuits, ketamine acts on a receptor found widely throughout the brain. This raises a key question: how can a drug targeting such a common receptor produce such distinct and powerful subjective effects?

04 Jul

ketamine

Spotlight: Yale presents “New Insights into the Neural Mechanisms of NMDA Receptor Antagonists Driving Rapid-Acting Antidepressant Effects” (Cichon, 2026)

"ketamine works on depression within minutes of infusion, lasting multiple days, if not weeks... amazing that it was classified as an anesthetic... twice as good as SSRI standards of care... leads to new formation of synapse, underlying sustaining mechanisms..."

26 May

Spotlight: Documentary "The Eternal Song"

Little Singer Welcome to The Eternal Song - The Eternal SongRegister to view the FULL film and gain access to the

19 May

ketamine research

Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells (Korkmaz, et al, 2026)

"findings suggest that ketamine exhibits potential anti-proliferative and pro-apoptotic effects on HT-29 colorectal cancer cells in vitro."

04 May

Aldous Huxley in 1958 on The Dictatorship of the "Future"

21 Apr

psychedelic research

Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)

DMT compared with ketamine variant, esketamine in mice.

26 Mar

social media addiction

Feature: Social media companies found liable in addiction cases

Meta owns Facebook, Instagram, Whatsapp and YouTube is owned by Google

25 Mar

ketamine harm reduction

Rational Ketamine Practice and the Current Ketamine Discourse

(Drafts ongoing)

17 Mar

psychedelic-assisted psychotherapy

Spotlight: "A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program" (Horowitz, et al, 2026)

"To our knowledge, this is the largest published cohort of KAP in an academic palliative care context. Our Pal-KAP experience suggests that KAP can be delivered safely and ethically, providing a practical blueprint for programs exploring innovative ways to address Psychospiritual distress (PSD)"

05 Mar

ketamine

Rapid Improvement in Consciousness After Low-Dose Ketamine in a Patient With Acute Confusion: A Case Report (Khalafallah Khalid, et al, 2025)

"While anecdotal, such findings align with emerging literature and warrant further exploration of ketamine's neurocognitive effects beyond its established indications."

11 Jan

psilocybin

Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation (Irrmischer, et al, 2025)

"Findings indicate that individual psilocybin-assisted therapy has the potential for beneficial effects on mood and personality characteristics. Moreover, the study highlights the importance of subjective experiences and demographic factors in moderating this effect."

20 Nov