Psychedelic Mental Health
Psychedelic Mental Health
Psychedelic Practice, Research & Advocacy
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Psychedelic Mental Health
psychedelic research

Spotlight: The Role of Psychedelics in Contemporary Psychological and Interdisciplinary Inquiry (Soylemez, et al, 2025)

"These compounds have been shown to enable access to unconscious cognitive and emotional content, facilitate emotional release, and induce a temporary dissolution of ego boundaries—processes that may underpin significant and enduring therapeutic outcomes."
Michael DeMarco, PhD

by Michael DeMarco, PhD

(2025):"Integration, which is the process of making sense of and incorporating insights from the psychedelic experience, is essential for lasting therapeutic benefit [42]. Without integration, the profound realizations and emotional breakthroughs may fade or become confusing. Therapeutic models increasingly emphasize preparation and post-session integration as critical components of psychedelic therapy [43]. Integration may involve psychotherapy, journaling, mindfulness practices, or community support, all aimed at reinforcing positive changes and addressing any lingering challenges."

More like this

What's ketamine psychedelic therapy like? Reviewing 5 years of real-world practice data

Michael DeMarco, PhD, Psychedelic Practitioner & Consultant

¿Cómo es la terapia con ketamina? Repasando 5 años de viajes

Michael DeMarco, PhD

Spotlight: Jeffrey Becker - The Neurobiology Underlying Transcendence Induced by Ketamine and the Psychedelics (2026)

While psychedelics selectively amplify activity in specific neural circuits, ketamine acts on a receptor found widely throughout the brain. This raises a key question: how can a drug targeting such a common receptor produce such distinct and powerful subjective effects?

Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)

DMT compared with ketamine variant, esketamine in mice.

Spotlight: "A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program" (Horowitz, et al, 2026)

"To our knowledge, this is the largest published cohort of KAP in an academic palliative care context. Our Pal-KAP experience suggests that KAP can be delivered safely and ethically, providing a practical blueprint for programs exploring innovative ways to address Psychospiritual distress (PSD)"

Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation (Irrmischer, et al, 2025)

"Findings indicate that individual psilocybin-assisted therapy has the potential for beneficial effects on mood and personality characteristics. Moreover, the study highlights the importance of subjective experiences and demographic factors in moderating this effect."