Psychedelic Mental Health Institute
Psychedelic Mental Health Institute
Psychedelic Community of Practice & Research
⌘K
Contact
Psychedelic Mental Health Institute
ketamine research

Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells (Korkmaz, et al, 2026)

"findings suggest that ketamine exhibits potential anti-proliferative and pro-apoptotic effects on HT-29 colorectal cancer cells in vitro."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Ketamine Induces Apoptosis and Inhibits Proliferation in HT-29 Colorectal Cancer Cells - PubMed
<span><b>Background</b>: Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains a major health concern due to its high recurrence and mortality rates. Recent studies suggest that anesthetic agents, including ketamine, may have direct effects on cancer cell viability and ap</span> …
PubMedIrmak Fatoş Korkmaz

(2026):"Ketamine significantly reduced cell viability in a dose-dependent manner, with an IC50 value of approximately 1.05 µM. Flow cytometry analysis demonstrated a marked increase in early apoptosis (23.9%) in treated cells. These findings suggest that ketamine exhibits potential anti-proliferative and pro-apoptotic effects on HT-29 colorectal cancer cells. Conclusions: These findings suggest that ketamine exhibits potential anti-proliferative and pro-apoptotic effects on HT-29 colorectal cancer cells in vitro. Further studies are warranted to elucidate the underlying molecular mechanisms and potential clinical implications."

La ketamina induce apoptosis e inhibe la proliferación en células de cáncer colorrectal HT-29 (Korkmaz, et al, 2026)

"La ketamina redujo significativamente la viabilidad celular de una manera dependiente de la dosis, con un valor de CI50 de aproximadamente 1,05 pM. El análisis de citometría de flujo demostró un aumento marcado en la apoptosis temprana (23,9%) en las células tratadas. Estos hallazgos sugieren que la ketamina exhibe posibles efectos antiproliferativos y pro-apoptóticos sobre las células de cáncer colorrectal HT-29. Conclusiones: Estos hallazgos sugieren que la ketamina exhibe posibles efectos antiproliferativos y pro-apoptóticos sobre las células de cáncer colorrectal HT-29 in vitro. Se justifican más estudios para dilucidar los mecanismos moleculares subyacentes y las posibles implicaciones clínicas"."

More like this

Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)

DMT compared with ketamine variant, esketamine in mice.
Spotlight: "A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program" (Horowitz, et al, 2026)

Spotlight: "A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program" (Horowitz, et al, 2026)

"To our knowledge, this is the largest published cohort of KAP in an academic palliative care context. Our Pal-KAP experience suggests that KAP can be delivered safely and ethically, providing a practical blueprint for programs exploring innovative ways to address Psychospiritual distress (PSD)"

Rapid Improvement in Consciousness After Low-Dose Ketamine in a Patient With Acute Confusion: A Case Report (Khalafallah Khalid, et al, 2025)

"While anecdotal, such findings align with emerging literature and warrant further exploration of ketamine's neurocognitive effects beyond its established indications."

Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis (Elmosalamy, et al, 2025)

"Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster."

Unfolding States of Mind: A Dissociative-Psychedelic Model of Ketamine-Assisted Psychotherapy in Palliative Care (Gonçalves Campolina & Tuena de Oliveira, 2025)

Dissociative-psychedelic model offers a compassionate, pragmatic, theoretically grounded approach to relieving psychological & existential suffering in palliative care

Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanoma (skin cancer) (Idoudi, et al, 2025)

"These findings demonstrate that ketamine, particularly when combined with DDM, holds promise as a potential topical therapeutic strategy against melanoma."
Mastodon Mastodon