Evaluating oral ketamine's adverse side effects in chronic pain patients (Hom, et al, 2025)
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Ketamine has a psychedelic effect and an anesthetic modulation of brain microtubules. How this mechanism works, according to the principles of the Orchestrated Objective Reduction, shared by the Penrose-Hameroff (Orch-OR) consciousness model.
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"Although ketamine's mode of action is distinct from classic psychedelics, patients frequently report similar alterations in consciousness, including experiences described as spiritual or religious"
Spotlight: Jeffrey Becker - The Neurobiology Underlying Transcendence Induced by Ketamine and the Psychedelics (2026)
While psychedelics selectively amplify activity in specific neural circuits, ketamine acts on a receptor found widely throughout the brain. This raises a key question: how can a drug targeting such a common receptor produce such distinct and powerful subjective effects?
Spotlight: Yale presents “New Insights into the Neural Mechanisms of NMDA Receptor Antagonists Driving Rapid-Acting Antidepressant Effects” (Cichon, 2026)
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Spotlight: N,N-dimethyltryptamine elicits antidepressant and anxiolytic effects in helpless mice: a comparative study with S-ketamine (da Sousa-Silva, et al, 2026)
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