ketamine
Spotlight: Understanding the Experience of Ketamine-Assisted Therapy and the Importance of Context (Stockwell, et al, 2025) Comprender la experiencia de la terapia asistida por ketamina y la importancia del contexto
"comfort in the setting supported participants to let go and was facilitated by learning about the therapist's personal experiences, a strong therapeutic alliance, and feeling safe...music also influenced the experience, facilitating a spiritual journey guiding the experience."
ketamine-assisted psychotherapy
Psychedelics in Palliative Care, Marcia Glass, Ed., Oxford University Press
with contributions by Psychedelic Institute fellows, Michael DeMarco, PhD and Thaís Salles Araujo, MD on ketamine, psilocybin mushrooms in palliative care
at home ketamine therapy
Spotlight: Ketamine’s Rapid Antidepressant Effects Mapped Brain-Wide + μ-opioid receptor?
"The deployment of mesoscale brain-wide fluctuation analysis unveils the complex, multiregional neural orchestration underlying ketamine’s rapid antidepressant effects, a blueprint for future therapeutic innovation... insights gained from this research hold transformative promise..."
mechanisms of action
Spotlight: Triple-network model-based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials (Lin, et al, 2025)
"These findings may support the utility of the triple-network model in elucidating ketamine's antidepressant effect. Alterations in DMN, salience and FPN function may underlie this effect."
ketamine
Spotlight: Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm (MacConnel, et al, 2024)
"Administering ketamine in ways that parallel psychedelic-assisted treatments—including preparatory, integration, sensory immersion, and psychotherapy sessions—could decrease PTSD symptoms meaningfully."
hallucinogen rating scale
Psychedelic Ketamine Assisted Psychotherapy & Support - Prelimary Analysis
On the the Hallucinogen Rating Scale (HRS), a widely used tool for measuring subjective effects of psychedelics and other psychoactive substances and real-world ketamine assisted therapy practice data
recovery
Spotlight: Smart Recovery & Psychedelic-Assisted Psychotherapy
On Psychedelics in Recovery
ketamine
Spotlight: Recent study finds ketamine described as having visual effects, outranking many serotonergic psychedelics and plant medicines
Ketamine was described with visual words more often than mushrooms and LSD according to a LLM analysis of Erowid data. DMT was the most described using visual words
at home ketamine
Spotlight: Ketamine Lit Review on Mastodon (a site not owned by fascists)
Over 800 posts to date! See what's new in ongoing ketamine research spanning over 60 years.
psychedelics
The Neuroscience of Ketamine, Psychedelics, and Meditation Experiences
Neural correlates and subjective experiences in meditation, psychedelic medicines including ketamine: A preliminary, evolving review of the literature. (2026 updates)
cbt
Cognitive Behavioral Psychedelic Therapy
Cognitive Behavioral & Psychedelic / Therapy in the Research
at-home ketamine
Increasing Access to Psychedelic Mental Health : The "proliferation of ketamine clinics" narrative and cost considerations
Psychedelic and psychiatric medicines have been studied for over 100 years as adjuncts to mental health support, with over 60 years of ongoing research on the off-label use of racemic ketamine, a generic medicine administered in various routes of administration with varying levels of support care
ketamine-assisted psychotherapy
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health & Pain
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
