ketamine
Spotlight: Real world effectiveness of maintenance ketamine infusions for treatment-resistant depression in major depressive disorder and bipolar disorder (Haikazian, et al, 2025)
"Ketamine was determined to be relatively safe, with zero cases of suicidal behaviour and addiction behaviour throughout treatment."
ketamine
Spotlight "Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant" (Fong, et al, 2025)
"Persistent passive coping (p-coping) behaviour is a hallmark feature in major depression and is reversed by fast-acting antidepressants (such as ketamine)."
iv ketamine
Spotlight: "Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study" (Singh, et al, 2025)
Observational study provides evidence regarding longer durability of generic IV ketamine compared to intranasal esketamine (Spravato).
ketamine therapy
Revisiting Ketamine (after 5 years)
A lot has changed in my life since my first ketamine journey...
at home ketamine
Spotlight: Ketamine Lit Review on Mastodon (a site not owned by fascists)
Over 800 posts to date! See what's new in ongoing ketamine research spanning over 60 years.
psychedelics
The Neuroscience of Ketamine, Psychedelics, and Meditation Experiences
Neural correlates and subjective experiences in meditation, psychedelic medicines including ketamine: A preliminary, evolving review of the literature. (2026 updates)
at-home ketamine
Increasing Access to Psychedelic Mental Health : The "proliferation of ketamine clinics" narrative and cost considerations
Psychedelic and psychiatric medicines have been studied for over 100 years as adjuncts to mental health support, with over 60 years of ongoing research on the off-label use of racemic ketamine, a generic medicine administered in various routes of administration with varying levels of support care
ketamine-assisted psychotherapy
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health & Pain
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
