Spotlight: Psychedelics in Palliative Care, Ready for Primetime! Making the Case for Ketamine-Assisted Psychotherapy (Horowitz, et al, 2024)
"Preliminary evidence demonstrates that Ketamine-Assisted Psychotherapy (KAP) can significantly improve depression, demoralization and existential distress in seriously ill people"

In which patients in the ICU remained stable, with transient shifts in mood and blood pressure, appearing less sad, and reporting to be less sad while in the ICU.
Ketamine, used under direction, is safe in most people, including critically ill patients in the ICU, and may lead to a personally meaningful mystical experience that reduces suffering.