ketamine harm reduction
Rational Ketamine Practice and the Current Ketamine Discourse
(Drafts ongoing)
Michael DeMarco, PhD
Michael DeMarco, PhD | Life Coach, Psychedelic Ketamine Preparation & Integration, Sex Therapy
Mental health support through psychotherapy, life coaching, psychedelic ketamine preparation & integration, sex therapy
Psychedelic harm reduction coaching
Michael DeMarco, PhD
Remote Telehealth Life Coach | Rational Emotive Behavioral Coaching, Cognitive Behavioral Coaching | Board Certified Clinical Sexologist | Psychedelic Consultant & Integration Coach | Ketamine Preparation, Support and Integration Coach, Supervisor | Psychedelic Practitioner
Michael DeMarco, PhD
About the Psychedelic Institute
Psychedelic Institute of Mental Health & Family Therapy offers support, training and practice in psychedelic-assisted psychotherapy to clinician and non-clinical members
Michael DeMarco, PhD
INSTITUTO PSICODÉLICO DE SALUD MENTAL Y TERAPIA FAMILIAR
Un centro de estudios en psicodelia que aboga por el estudio y la práctica seguros y legales de las experiencias de la medicina psicodélica y su aplicación a la salud mental y el bienestar | Uruguay
Michael DeMarco, PhD
Psychedelic-Assisted Psychotherapy — Rates, Referrals & Registration
Psychotherapy therapy, support, and case management via telehealth from the Psychedelic Institute of Mental Health & Family Therapy
Michael DeMarco, PhD
Is ketamine a “psychedelic”?
Yes.
Michael DeMarco, PhD
Ketamine is used in psychedelic assisted psychotherapy
Psychedelic Cognitive Behavioral Therapy: On Ketamine, Context, and Competencies in “Assisted-Psychotherapy”
There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.
Michael DeMarco, PhD
Psychedelic Therapy: Does the psychedelic experience matter?
Psychedelic medicines have been studied in the Western medical literature consistently for over 100 years, over 60 of which in the ongoing study and practice of racemic ketamine. Psychedelic experiences are described similarly and often felt as profoundly meaningful.
Michael DeMarco, PhD
Neural correlates and subjective experiences in meditation vs psychedelics, including ketamine (Preliminary Lit Review)
A preliminary, evolving review of the literature. (Ongoing Draft) | Psychedelic Institute of Mental Health & Family Therapy
Michael DeMarco, PhD
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
Michael DeMarco, PhD
Psychedelic Therapy Research
psychedelic-assisted psychotherapy
Spotlight: "A Blueprint for Implementing Ketamine-Assisted Psychotherapy in Palliative Care: Design, Process, and Treatment Patterns of a Real-World Clinical Program" (Horowitz, et al, 2026)
"To our knowledge, this is the largest published cohort of KAP in an academic palliative care context. Our Pal-KAP experience suggests that KAP can be delivered safely and ethically, providing a practical blueprint for programs exploring innovative ways to address Psychospiritual distress (PSD)"
ketamine
Rapid Improvement in Consciousness After Low-Dose Ketamine in a Patient With Acute Confusion: A Case Report (Khalafallah Khalid, et al, 2025)
"While anecdotal, such findings align with emerging literature and warrant further exploration of ketamine's neurocognitive effects beyond its established indications."
psilocybin
Moderating factors in psilocybin-assisted treatment affecting mood and personality: A naturalistic, open-label investigation (Irrmischer, et al, 2025)
"Findings indicate that individual psilocybin-assisted therapy has the potential for beneficial effects on mood and personality characteristics. Moreover, the study highlights the importance of subjective experiences and demographic factors in moderating this effect."
psychedelics
Psychedelic Experiences After Bereavement Improve Symptoms of Grief: The Influence of Emotional Breakthroughs and Challenging Experiences (Low, et al, 2025)
"Findings provide preliminary evidence that support the development of a psychedelic-assisted therapy protocol to target symptoms of grief. Psychedelic-assisted therapy might offer an alternative to current grief treatment options. "
ketamine
Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis (Elmosalamy, et al, 2025)
"Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster."
ketamina
Ketamina en Cirugía Cardíaca: Una Revisión Sistemática y un Meta-Análisis de Efectos sobre Marcadores Inflamatorios y Resultados Clínicos (Ferreira de Lima E Souza, et al, 2025)
La medicina psicodélica ketamina, utilizada desde hace décadas en anestesia, manejo del dolor, salud mental y cuidados paliativos, ha sido administrada en pacientes cardíacos sin observarse cambios negativos en los resultados clínicos atribuibles a efectos adversos del fármaco.