Spotlight: Symptom modulation and tolerability of intravenous ketamine in treatment-resistant bipolar depression: A retrospective study (Cuomo, et al, 2025)
The review underscores the safety and efficacy of ketamine for patients with Bipolar Disorder.
Symptom modulation and tolerability of intravenous ketamine in treatment-resistant bipolar depression: A retrospective study - PubMed
Ketamine’s use in treating bipolar depression must account for risks, such as switching to manic episodes or worsening symptoms. This study examines ketamine’s impact on depressive symptoms, focusing on ‘inner tension,’ ‘sleep reduction,’ and ‘suicidal ideation’ over four weeks in treatment-resistan …
Alessandro Cuomo
"No ketamine-treated patient experienced a manic switch during the observation period. A statistically significant decrease (i.e., improvement) in MADRS global score and scores on the Internal Tension, Reduced Sleep, and Suicidal Ideation items was observed from the second week, with no evidence of worsening of the above symptoms. Patient-reported adverse events were generally mild to moderate."
