Spotlight: "Ketamine may treat depression by 'flattening the brain's hierarchies,' small study suggests (2025)

"The finding of increased synaptic density in the DMN suggests ketamine isn't just creating new synapses — it's fundamentally reorganizing how brain networks communicate."

Ketamine may work by ‘flattening the brain’s hierarchies,’ brain scans suggest
Ketamine leads to increased communication between areas of the brain that don’t typically engage with each other, new research suggests.
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