"N,N-Dimethyltryptamine (DMT) is a naturally occurring amine and psychedelic compound, found in plants, animals, and humans. "
Exploring DMT: Endogenous role and therapeutic potential (Schimmelpfennig, et al, 2025)
https://www.sciencedirect.com/science/article/pii/S0028390825000206
from the book "Tell Me What You Want"
"Persistent passive coping (p-coping) behaviour is a hallmark feature in major depression and is reversed by fast-acting antidepressants (such as ketamine)."
"The finding of increased synaptic density in the DMN suggests ketamine isn't just creating new synapses — it's fundamentally reorganizing how brain networks communicate."
"While more research is needed to fully characterize the safety profile, current data support a relatively benign adverse effect profile with good tolerability when administered responsibly and in accordance with clinical standards to individuals without known contraindications."