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Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model (Dong, et al, 2025)

"Ketamine sustains and boosts Ketogenic Diet benefits for > 10 days, supporting clinical findings that short-term KGD + KET may be an effective treatment for preventing anorexia nervosa relapses."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model - PubMed
Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine (KET) is an effective treatment. The animal model, Activity-Based Anorexia (ABA), captures AN’s mala …
PubMedYiru Dong

(2025): "EM revealed that KGD increases GABAergic synapse lengths and may reduce ABA vulnerability by increasing excitatory synaptic drive of GABAergic interneurons and increasing E-to-E synapses' role in body weight regulation."

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