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Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model (Dong, et al, 2025)

"Ketamine sustains and boosts Ketogenic Diet benefits for > 10 days, supporting clinical findings that short-term KGD + KET may be an effective treatment for preventing anorexia nervosa relapses."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model - PubMed
Anorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine (KET) is an effective treatment. The animal model, Activity-Based Anorexia (ABA), captures AN’s mala …
PubMedYiru Dong

(2025): "EM revealed that KGD increases GABAergic synapse lengths and may reduce ABA vulnerability by increasing excitatory synaptic drive of GABAergic interneurons and increasing E-to-E synapses' role in body weight regulation."

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Change in the Neural Response to Auditory Deviance Following Cognitive Therapy for Hallucinations in Patients With Schizophrenia (Knott, et al, 2020)

"These findings of improved auditory information processing and symptom-response attributable to CBTv suggest potential clinical and functional benefits of psychotherapeutical approaches for patients with persistent AVHs."

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Spotlight: The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal (Lehane, et al, 2025)

"These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal. "

Naltrexone in the Treatment of Ketamine Use Disorders: A Case Report and Literature Review (Verma, et al, 2025)

"findings consistent w/ 2 prior reports - use of naltrexone in KUDs at the dosage of 50 mg/day successfully helped patients achieve abstinence... naltrexone reduces antidepressant effects of ketamine, indicating overlap between opioid system & ketamine's NMDA receptor activity. "

Spotlight: Ketamine for treatment-resistant post-traumatic stress disorder: double-blind active-controlled randomised crossover study (Beaglehole, et al, 2025)

"We provide preliminary support for the efficacy and tolerability of i.m. ketamine in a community sample of individuals with PTSD."

Spotlight: The transformational power of psychedelics: catalysts for creativity, consciousness, and mental health (Du, et al, 2025)

"Psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), ketamine, and N,N-dimethyltryptamine (DMT), have captured the attention of scientists, artists, and seekers alike for their profound ability to alter consciousness and inspire creativity."
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