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Spotlight: Synaptic priming: A framework for pharmacotherapy in depression (Brown, et al, 2025)

"we describe how the indirect relationship between ketamine's pharmacokinetics and sustained antidepressant pharmacodynamics reveals a dosing model (primer pharmacology) that can be harnessed to fine-tune therapeutic outcomes."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Synaptic priming: A framework for pharmacotherapy in depression - PubMed
Recent antidepressant drug development focuses on a next generation of drugs to rapidly relieve symptoms. Yet, how ketamine, the prototype rapid-acting antidepressant, maintains symptom relief days after drug elimination, and how repeated doses sustain longer-lasting therapeutic effects, remains unc …
PubMedKyle A Brown

(2025)

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Spotlight: Antidepressants and the endogenous opioid system (Fricker, et al, 2025)

"A growing body of evidence links the opioid system w/ major depressive disorder... two different widely used antidepressants, tianeptine & ketamine, both interact with MOR; tianeptine as a full agonist, ketamine as a positive allosteric modulator. Both produce antidepressant effects within days."
Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment (Massaneda-Tuneu, et al, 2025)

Spotlight: Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment (Massaneda-Tuneu, et al, 2025)

"Findings suggested that racemic ketamine (including by mouth), when appropriately dosed and administered within a structured clinical and safety monitoring framework, is both effective, safe and well-tolerated over a 6-month treatment period."
Natalya Gevorgyan is the Founder of The Magic Church, a nonprofit exploring the intersection of science, spirituality, and sacred practice in the study of psilocybin.

Spotlight: The Magic Church

Natalya Gevorgyan is the Founder of The Magic Church, a nonprofit exploring the intersection of science, spirituality, and sacred practice in the study of psilocybin.

Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model (Dong, et al, 2025)

"Ketamine sustains and boosts Ketogenic Diet benefits for > 10 days, supporting clinical findings that short-term KGD + KET may be an effective treatment for preventing anorexia nervosa relapses."

Change in the Neural Response to Auditory Deviance Following Cognitive Therapy for Hallucinations in Patients With Schizophrenia (Knott, et al, 2020)

"These findings of improved auditory information processing and symptom-response attributable to CBTv suggest potential clinical and functional benefits of psychotherapeutical approaches for patients with persistent AVHs."

Spotlight: Ketamine Harm Reduction

Prevention & Treatment in Ketamine Use Disorder - When a medicine becomes a poison
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