Psychedelic Institute of Mental Health & Family Therapy
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Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis (Elmosalamy, et al, 2025)

"Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Intravenous ketamine versus esketamine for depression: a systematic review and meta-analysis - PubMed
The study protocol was prospectively registered on the Open Science Framework (OSF) at https://osf.io/5jzev.
PubMedAhmed Elmosalamy

Ketamina intravenosa versus esketamina para la depresión: una revisión sistemática y un metaanálisis (Salamy, et al, 2025) "Sobre la base de la evidencia comparativa disponible actualmente, que es casi completamente observacional, la ketamina IV y la esketamina IN muestran tasas comparables de respuesta aguda y remisión, aunque la ketamina IV puede actuar más rápido. Se necesitan grandes ECA de cabeza a cabeza para confirmar estos hallazgos."

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Psychedelic Experiences After Bereavement Improve Symptoms of Grief: The Influence of Emotional Breakthroughs and Challenging Experiences (Low, et al, 2025)

"Findings provide preliminary evidence that support the development of a psychedelic-assisted therapy protocol to target symptoms of grief. Psychedelic-assisted therapy might offer an alternative to current grief treatment options. "

Ketamina en Cirugía Cardíaca: Una Revisión Sistemática y un Meta-Análisis de Efectos sobre Marcadores Inflamatorios y Resultados Clínicos (Ferreira de Lima E Souza, et al, 2025)

La medicina psicodélica ketamina, utilizada desde hace décadas en anestesia, manejo del dolor, salud mental y cuidados paliativos, ha sido administrada en pacientes cardíacos sin observarse cambios negativos en los resultados clínicos atribuibles a efectos adversos del fármaco.

Unfolding States of Mind: A Dissociative-Psychedelic Model of Ketamine-Assisted Psychotherapy in Palliative Care (Gonçalves Campolina & Tuena de Oliveira, 2025)

Dissociative-psychedelic model offers a compassionate, pragmatic, theoretically grounded approach to relieving psychological & existential suffering in palliative care

Ketamine and dodecyl maltoside synergy as a potential topical therapeutic approach for melanoma (skin cancer) (Idoudi, et al, 2025)

"These findings demonstrate that ketamine, particularly when combined with DDM, holds promise as a potential topical therapeutic strategy against melanoma."

Racemic Ketamine vs Esketamine in Treatment-Resistant Depression: The Overlooked Role of Arketamine (Tan, et al, 2025)

Evidence suggests that "IV racemic ketamine is more effective than IN esketamine in TRD; convergent preclinical and clinical findings support the hypothesis that arketamine plays a key role in this superiority and that ketamine’s antidepressant mechanisms extend beyond simple NMDAR antagonism."

The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews (Correa de Costa, et al, 2025)

"...evidence suggests that the use of serotonergic and non-serotonergic psychedelics (ketamine) for the treatment of SUD may provide advantages over traditional therapeutics, and these compounds may eventually become part of the next generation of treatments for SUD under specific circumstances."
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