Evaluating oral ketamine's adverse side effects in chronic pain patients (Hom, et al, 2025)

"Findings provide preliminary evidence that support the development of a psychedelic-assisted therapy protocol to target symptoms of grief. Psychedelic-assisted therapy might offer an alternative to current grief treatment options. "

"Based on the currently available comparative evidence, which is almost entirely observational, IV ketamine and IN esketamine show comparable acute response and remission rates, though IV ketamine may act faster."

La medicina psicodélica ketamina, utilizada desde hace décadas en anestesia, manejo del dolor, salud mental y cuidados paliativos, ha sido administrada en pacientes cardíacos sin observarse cambios negativos en los resultados clínicos atribuibles a efectos adversos del fármaco.

Dissociative-psychedelic model offers a compassionate, pragmatic, theoretically grounded approach to relieving psychological & existential suffering in palliative care

"These findings demonstrate that ketamine, particularly when combined with DDM, holds promise as a potential topical therapeutic strategy against melanoma."

Evidence suggests that "IV racemic ketamine is more effective than IN esketamine in TRD; convergent preclinical and clinical findings support the hypothesis that arketamine plays a key role in this superiority and that ketamine’s antidepressant mechanisms extend beyond simple NMDAR antagonism."