Psychedelic Institute of Mental Health & Family Therapy
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cognitive behavioral therapy

Change in the Neural Response to Auditory Deviance Following Cognitive Therapy for Hallucinations in Patients With Schizophrenia (Knott, et al, 2020)

"These findings of improved auditory information processing and symptom-response attributable to CBTv suggest potential clinical and functional benefits of psychotherapeutical approaches for patients with persistent AVHs."
Michael DeMarco, PhD

by Michael DeMarco, PhD

Change in the Neural Response to Auditory Deviance Following Cognitive Therapy for Hallucinations in Patients With Schizophrenia - PMC
Adjunctive psychotherapeutic approaches recommended for patients with schizophrenia (SZ) who are fully or partially resistant to pharmacotherapy have rarely utilized biomarkers to enhance the understanding of treatment-effective mechanisms. As SZ…
NCBI home page

Schizophrenia has been studied theoretically using ketamine. Cognitive behavioral therapy has shown effects on non-medicine patient groups, patients receiving ketamine, and patients diagnosed with schizophrenia.

Impaired deviance detection as the core psychopathological mechanism of schizophrenia - PubMed
Understanding the core psychopathological mechanism of schizophrenia is crucial for its diagnosis and treatment. In this article, we update the evidence for our previous proposal that the core of neurocognitive dysfunctions in schizophrenia is the impairment of deviance detection. We discuss the dys …
PubMedYi Fan Zhang

(2025): "Integration of numerous findings into this model provides compelling evidence that impaired deviance detection is a prominent contributor to the manifestation of symptoms and the pathological progression of this psychiatric condition. We suggest that targeting the core cognitive deficiency, that of deviance detection may enhance psychological and pharmacological approaches to diagnose and rehabilitate schizophrenia." Cognitive behavioral therapy is one such approach.

Psychedelic Cognitive Behavioral Therapy: On Ketamine, Context, and Competencies in “Assisted-Psychotherapy”
There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.
Psychedelic Institute of Mental Health & Family TherapyMichael DeMarco, PhD

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Spotlight: Changing your mind: neuroplastic mechanisms underlying the therapeutic effect of psychedelics in depression, PTSD, and addiction (Palhas, et al, 2025)

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Studies suggest that human support is a factor in ketamine psychedelic therapy

Spotlight: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression (Taraku, et al, 2025)

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