ketamine
Spotlight: Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis (Silberbauer, et al, 2025)
Treatment was well-tolerated, with no serious adverse events reported...in a total of 592 patients, meta-analysis of randomized controlled trials on oral ketamine treatment demonstrated its antidepressant efficacy with a Number Needed to Treat = 4.89 for response and a NNT = 9.16 for remission.
at-home ketamine
Increasing Access to Psychedelic-Assisted Psychotherapy : The "proliferation of ketamine clinics" narrative and cost considerations
Psychedelic and psychiatric medicines have been studied for over 100 years as adjuncts to psychotherapy, with over 60 years of ongoing research on the off-label use of racemic ketamine, a generic medicine in various routes of administration with varying levels of support care
ketamine-assisted psychotherapy
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
