ketamine
Spotlight: Intravenous ketamine for suicide ideation in borderline personality and depression (Bachir, et al, 2025)
"This report highlights ketamine's rapid action on glutamate pathways and its potential benefits in complex psychiatric profiles where traditional treatments like electroconvulsive therapy often fail. "
ketamine
Spotlight: A retrospective analysis of ketamine intravenous therapy for post-traumatic stress disorder in real-world care settings (McInnes, et al, 2025)
"In a large real-world sample of 8,136 PTSD patients (87 % with comorbid depression), Ketamine Intravenous Therapy (KIT) significantly reduced PTSD and depression symptoms."
ketamine
Spotlight: The association between amygdalar volume changes and depressive symptom improvements after repeated ketamine infusion in treatment-resistant depression (2025)
"The reductions in right LB volumes correlate with better clinical responses to ketamine in patients with TRD, suggesting ketamine may exert its effect by attenuating amygdalar overactivity in this population."
ketamine
Spotlight: Real world effectiveness of maintenance ketamine infusions for treatment-resistant depression in major depressive disorder and bipolar disorder (Haikazian, et al, 2025)
"Ketamine was determined to be relatively safe, with zero cases of suicidal behaviour and addiction behaviour throughout treatment."
ketamine
Spotlight "Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant" (Fong, et al, 2025)
"Persistent passive coping (p-coping) behaviour is a hallmark feature in major depression and is reversed by fast-acting antidepressants (such as ketamine)."
ketamine
Spotlight: Ketamine as an Adjunct Therapy for Refractory Cancer Pain: A Case Report (Emshoff, et al, 2025)
"While traditionally recognized for its anesthetic and dissociative effects, low-dose, subanesthetic ketamine can be useful in palliative care to manage severe, intractable pain."
uruguay
Enfoque Uruguay: Propuesta -- Estrategia Nacional de Drogas 2026-2030. Junta Nacional de Drogas
Programa Piloto de Psicoterapia Asistida con Psicodélicos en el Sistema de Salud Uruguayo | Michael DeMarco, PhD
uruguay
Propuesta para la Estrategia Nacional de Drogas 2026–2030
Programa Piloto de Psicoterapia Asistida con Psicodélicos en el Sistema de Salud Uruguayo
ketamine
Spotlight: Understanding the Experience of Ketamine-Assisted Therapy and the Importance of Context (Stockwell, et al, 2025) Comprender la experiencia de la terapia asistida por ketamina y la importancia del contexto
"comfort in the setting supported participants to let go and was facilitated by learning about the therapist's personal experiences, a strong therapeutic alliance, and feeling safe...music also influenced the experience, facilitating a spiritual journey guiding the experience."
ketamine-assisted psychotherapy
Psychedelics in Palliative Care, Marcia Glass, Ed., Oxford University Press
with contributions by Psychedelic Institute fellows, Michael DeMarco, PhD and Thaís Salles Araujo, MD on ketamine, psilocybin mushrooms in palliative care
at home ketamine therapy
Spotlight: Ketamine’s Rapid Antidepressant Effects Mapped Brain-Wide + μ-opioid receptor?
"The deployment of mesoscale brain-wide fluctuation analysis unveils the complex, multiregional neural orchestration underlying ketamine’s rapid antidepressant effects, a blueprint for future therapeutic innovation... insights gained from this research hold transformative promise..."
mechanisms of action
Spotlight: Triple-network model-based graph theory analysis of the effectiveness of low-dose ketamine in patients with treatment-resistant depression: two resting-state functional MRI clinical trials (Lin, et al, 2025)
"These findings may support the utility of the triple-network model in elucidating ketamine's antidepressant effect. Alterations in DMN, salience and FPN function may underlie this effect."
ketamine
Spotlight: Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm (MacConnel, et al, 2024)
"Administering ketamine in ways that parallel psychedelic-assisted treatments—including preparatory, integration, sensory immersion, and psychotherapy sessions—could decrease PTSD symptoms meaningfully."
hallucinogen rating scale
Psychedelic Ketamine Assisted Psychotherapy & Support - Prelimary Analysis
On the the Hallucinogen Rating Scale (HRS), a widely used tool for measuring subjective effects of psychedelics and other psychoactive substances and real-world ketamine assisted therapy practice data
recovery
Spotlight: Smart Recovery & Psychedelic-Assisted Psychotherapy
On Psychedelics in Recovery
ketamine
Spotlight: Recent study finds ketamine described as having visual effects, outranking many serotonergic psychedelics and plant medicines
Ketamine was described with visual words more often than mushrooms and LSD according to a LLM analysis of Erowid data. DMT was the most described using visual words
at home ketamine
Spotlight: Ketamine Lit Review on Mastodon (a site not owned by fascists)
Over 800 posts to date! See what's new in ongoing ketamine research spanning over 60 years.
psychedelics
Neural correlates and subjective experiences in meditation vs psychedelics, including ketamine (Preliminary Lit Review)
A preliminary, evolving review of the literature. (Ongoing Draft) | Psychedelic Institute of Mental Health & Family Therapy
