Ketamine was FDA approved for use in high, anesthetic doses for humans and animals in 1970, and has been studied and used off-label since then for a number of other indications also supported by cognitive behavioral psychotherapy to avoid ketamine misuse, dependence and abuse.
ketamine-assisted psychotherapy
with contributions by Psychedelic Institute fellows, Michael DeMarco, PhD and Thaís Salles Araujo, MD on ketamine, psilocybin mushrooms in palliative care
at home ketamine therapy
"The deployment of mesoscale brain-wide fluctuation analysis unveils the complex, multiregional neural orchestration underlying ketamine’s rapid antidepressant effects, a blueprint for future therapeutic innovation... insights gained from this research hold transformative promise..."
mechanisms of action
"These findings may support the utility of the triple-network model in elucidating ketamine's antidepressant effect. Alterations in DMN, salience and FPN function may underlie this effect."
ketamine
"Administering ketamine in ways that parallel psychedelic-assisted treatments—including preparatory, integration, sensory immersion, and psychotherapy sessions—could decrease PTSD symptoms meaningfully."
hallucinogen rating scale
On the the Hallucinogen Rating Scale (HRS), a widely used tool for measuring subjective effects of psychedelics and other psychoactive substances and real-world ketamine assisted therapy practice data
recovery
On Psychedelics in Recovery
ketamine
Ketamine was described with visual words more often than mushrooms and LSD according to a LLM analysis of Erowid data. DMT was the most described using visual words
at home ketamine
Over 800 posts to date! See what's new in ongoing ketamine research spanning over 60 years.
psychedelics
A preliminary, evolving review of the literature. (Ongoing Draft) | Psychedelic Institute of Mental Health & Family Therapy
cbt
There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.
at-home ketamine
Psychedelic and psychiatric medicines have been studied for over 100 years as adjuncts to psychotherapy, with over 60 years of ongoing research on the off-label use of racemic ketamine, a generic medicine in various routes of administration with varying levels of support care
ketamine-assisted psychotherapy
"A systematic review of PO and SL ketamine noted no significant side effects, and no problems with tolerance or substance misuse in any of the studies, which totaled 140 patients who received ketamine up to 3 years in duration…” (Swainson, 2022)