ketamine
Spotlight "Prefrontal contribution to passive coping behaviour in chronic stress and treatment by fast-acting antidepressant" (Fong, et al, 2025)
"Persistent passive coping (p-coping) behaviour is a hallmark feature in major depression and is reversed by fast-acting antidepressants (such as ketamine)."
iv ketamine
Spotlight: "Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study" (Singh, et al, 2025)
Observational study provides evidence regarding longer durability of generic IV ketamine compared to intranasal esketamine (Spravato).
depression
Spotlight: Nearly half of depression diagnoses could be considered treatment-resistant (ScienceDaily, 2025)
Mixed methods study found hopelessness among patients struggling with condition after trying multiple antidepressants
