Psychedelic-Assisted Psychotherapy

An overview of psychotherapy in combination with medicines that elicit a "psychedelic" experience | The Psychedelic Institute of Mental Health & Family Therapy | Telehealth CA, NY, UT, VT | Palm Springs | Joshua Tree | Coachella

Psychedelic-assisted psychotherapy is an experiential type of therapy which prepares, and supports the psychedelic experience as something meaningful to your ongoing mental health and well-being.

Cultures and communities around the world support the psychedelic experience through what Westerners generally call “shamanic” practices, although many of these healers would not use that label. In Western medicine, the support for this type of medicine work has been studied and practiced in conjunction with specially trained psychotherapists.

Research spanning more than 100 years suggests that medicines that elicit the psychedelic experience may have an ongoing positive psychological benefit for most people. Psychedelic-assisted therapy is currently being shown in studies to improve some chronic and persistent mental health issues including anxiety, treatment-resistant depression, post traumatic stress disorder (PTSD), and end-of-life / death anxiety in people with chronic and/or terminal illnesses, chemical dependency issues and eating disorders.


“We can’t start history of psychedelics in the ‘60s in the Americas; that needs to stop. We [indigenous people] used this medicine before Jesus Christ walked this Earth.”

– Lisa M. Macias Red Bear, Injustice, Intersectional Trauma, and Psychedelics, 2017



OREGON PSILOCYBIN SERVICES ARE NOT MENTAL HEALTH TREATMENT


Special service centers in Oregon offer minimal support at various dosing ranging upwards of $3500 per session. These centers are not considered “psychedelic-assisted psychotherapy” or treatment for mental health conditions.


CLINICAL TRIALS THAT INCLUDE PSYCHEDELIC MEDICINES ARE NOT MENTAL HEALTH TREATMENTS, THEY ARE SCIENTIFIC STUDIES HTTPS://CLINICALTRIALS.GOV/

WHILE THE INSTITUTE CAN HELP YOU PREPARE AND INTEGRATE YOUR PERSONAL MEDICINE EXPERIENCES, WE CANNOT RECOMMEND OR ADMINISTER ANY MEDICINES OR COMPOUNDS.

“psychedelics reduce the weight of held beliefs and increase the weight of incoming sensory input, allowing the beliefs to be more readily changed by the new sensory information”

— Carhart-Harris & Friston 2019 – REBUS and the Anarchic Brain


PAIRING PSYCHEDELIC EXPERIENCES WITH COGNITIVE BEHAVIORAL THERAPY

Psychedelic Cognitive Behavioral Therapy: On Ketamine, Context and Competencies in “Assisted-Psychotherapy”
There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.

The Mystery of the Dream-Inducing Plants of Ancient Iran
Meet the powerful psychoactive plants known as Oneirogens

“We want for there to be greater knowledge of these ancestral plant medicine practices so that they do not become forgotten, and we believe that they are not the exclusive domain of anyone,” says Lu. “Yet, with availability and education, we also do not want for them to become so widespread that their origins are forgotten, taken for granted, or culturally appropriated.” 

PSYCHEDELIC INTEGRATION - A GOAL OF PSYCHOTHERAPY

Integration in psychotherapy is bearing witness and making meaning that lasts beyond the ayahuasca ceremony, magic mushroom velada, religious experience, meditation retreat, dream work, sexual ecstatic experience, or k-hole. These experiences may sometimes be considered mystical experiences or transpersonal experiences. A mind-body approach like cognitive behavioral therapy offers a framework to these experiences to become something beneficial in your life.

In this approach, your guide is not there to interpret your experience, but to help you apply what is helpful as your experience continues to unfold. You’re not done once the acute medicine administration is over. Integration within a bio-psycho-socio-spiritual framework of psychotherapy aims to help people maintain a sense of self-actualization that may result from transcendent experiences. Integration is what you DO with this mind-body approach called cognitive behavioral therapy once you’ve learned how to think about your thinking. Integration is learning to come to a deep understanding from within, what rational emotive behavior therapy (REBT) calls a radical philosophical shift, and what Maslow called “peak experiences”.

Psychotherapy is useful with or without psychedelics. The goal of integration is the same- to bear witness and feel safe, seen and heard, and to make meaning that leads to lasting improved overall quality of life. In cognitive behavioral therapy, this is done by learning how to think and correct the types of thinking that lead to ongoing mental illness and its effects on pain in the body, and physiological changes in the brain.

Integration may start with support from a mental health provider and be maintained by support in a variety of mind, body and/or philosophical/spiritual approaches for ongoing mental health practice at home as discussed with your licensed mental health provider.


ADDITIONAL READINGS, NEWS, RESEARCH, AND RESOURCES

Psychotherapist Tammy Nelson Discusses Couples Therapy and Ketamine— A New Way to Enrich Relationships — Psychedelic Therapy | Telehealth CA, NY, UT, VT | Greater Palm Springs | Joshua Tree
Read more about Dr. Nelson’s point of view on ketamine training and ketamine-assisted psychotherapy .
At-home, telehealth-supported ketamine treatment for depression: Findings from longitudinal, machine learning and symptom network analysis of real-world data - PubMed
At-home, telehealth-supported ketamine administration was largely safe, well-tolerated, and associated with improvement in patients with depression. Strategies for combining psychedelic-oriented therapies with rigorous telehealth models, as explored here, may uniquely address barriers to mental heal …
Preliminary evidence demonstrates that Ketamine-Assisted Psychotherapy (KAP) can significantly improve depression, demoralization and existential distress in seriously ill people. We will discuss: 1. the history and science of psychedelics; 2. ketamine pharmacology, and KAP indications and delivery models; 3. putative KAP mechanisms of action; and 4. examples of KAP program development, including making the case, potential obstacles, and creative solutions.

A comparison between psilocybin and esketamine in treatment-resistant depression using number needed to treat (NNT): A systematic review - PubMed
Relatively few pharmacologic agents are proven safe and effective in adults with TRD. NNT estimates for investigational psilocybin and esketamine in TRD indicate clinical meaningfulness. The NNH profile for both aforementioned agents is clinically acceptable. Our results underscore the clinical rele …
Relatively few pharmacologic agents are proven safe and effective in adults with TRD. NNT estimates for investigational psilocybin and esketamine in TRD indicate clinical meaningfulness. The NNH profile for both aforementioned agents is clinically acceptable. Our results underscore the clinical relevance of these treatment options in adults with TRD.

NUMBER NEEDED TO TREAT (NNT) FOR KETAMINE AND ESKETAMINE IN ADULTS WITH TREATMENT-RESISTANT DEPRESSION: A SYSTEMATIC REVIEW AND META-ANALYSIS (KWAN, ET AL, 2024)

A low number to treat and a high number to harm suggests efficacy and safety of racemic ketamine and esketamine across thousands of clients. It takes not very many ketamine treatments to help, and a large number of treatments to statiscally help and harm, also indicating a range of safe repeated dosing.

DEEP POSTEROMEDIAL CORTICAL RHYTHM IN DISSOCIATION (2020)

Deep posteromedial cortical rhythm in dissociation - Nature
Dissociative states in mouse and human brains are traced to low-frequency rhythmic neural activity—with distinct molecular, cellular and physiological properties—in the deep retrosplenial cortex and the posteromedial cortex.
Dissociation in human beings is a self-reported state of mind, and no experimental technique in rodents or in humans can currently define this subjective experience in full. However, the clinically guided paradigm reported here could provide a framework of behavioural, optical and physiological tools to enable exploration of the neural activity that underlies dissociative states (Vesuna, et al, 2019).

KETAMINE IN NEUROPSYCHIATRIC DISORDERS: AN UPDATE (JOHNSTON, ET AL, 2023)

Considerable clinical research supports the use of—or further research with—subanesthetic-dose ketamine and its (S)-enantiomer esketamine in multiple neuropsychiatric disorders including depression, bipolar disorder, anxiety spectrum disorders, substance use disorders, and eating disorders, as well as for the management of chronic pain.

DEVELOPMENT AND PSYCHOMETRIC VALIDATION OF A NOVEL SCALE FOR MEASURING ‘PSYCHEDELIC PREPAREDNESS’

‪Development and psychometric validation of a novel scale for measuring ‘psychedelic preparedness’‬
‪RG McAlpine, G Blackburne, SK Kamboj‬, ‪Scientific Reports, 2024‬ - ‪Cited by 9‬
Significant differences between those scoring high and low (on psychedelic preparedness) before the psychedelic experience were found on measures of mental health/wellbeing outcomes assessed after the experience, suggesting that the scale has predictive utility.

PSYCHEDELIC-ASSISTED THERAPY AND PSYCHEDELIC SCIENCE: A REVIEW AND PERSPECTIVE ON OPPORTUNITIES IN NEUROSURGERY AND NEURO-ONCOLOGY (2023)

Psychedelic-Assisted Therapy and Psychedelic Science: A... : Neurosurgery
nd lysergic acid diethylamide and nonclassic psychedelics 3,4-methylenedioxymethamphetamine and ketamine are increasingly appreciated as neuroplastogens given their potential to fundamentally alter mood and behavior well beyond the time window of measurable exposure. Imaging studies with psychedelics are also helping advance our understanding of neural networks and connectomics. This resurgence in psychedelic science and psychedelic-assisted therapy has potential significance for the fields of neurosurgery and neuro-oncology and their diverse and challenging patients, many of whom continue to have mental health issues and poor quality of life despite receiving state-of-the-art care. In this study, we review recent and ongoing clinical trials, the set and setting model of psychedelic-assisted therapy, potential risks and adverse events, proposed mechanisms of action, and provide a perspective on how the safe and evidence-based use of psychedelics could potentially benefit many patients, including those with brain tumors, pain syndromes, ruminative disorders, stroke, SAH, TBI, and movement disorders. By leveraging psychedelics’ neuroplastic potential to rehabilitate the mind and brain, novel treatments may be possible for many of these patient populations, in some instances working synergistically with current treatments and in some using subpsychedelic doses that do not require mind-altering effects for efficacy. This review aims to encourage broader multidisciplinary collaboration across the neurosciences to explore and help realize the transdiagnostic healing potential of psychedelics.…
While the neural underpinnings remain to be clarified, the psychedelic-induced state seems to allow one to recollect and process deep autobiographical information, achieve new understandings of one's self and relationships with others, and gain greater appreciation of one's place within the cosmos.5,61,62This state is closely linked to the concept of “mystical experience” which in multiple studies with classic psychedelics predicts therapeutic efficacy.9,11,45,47,55 “Ego dissolution” is another term used to describe a loss of the usual sense of self as separate entity.13 The quality and degree of psychedelic-induced ego dissolution and mystical experience are typically measured in clinical trials with validated psychometric instruments such as the 5-Dimensional Altered States of Consciousness Questionnaire and the Mystical Experience Questionnaire.9,11,45,47,49,55,61

THE NMDA RECEPTOR ANTAGONISTS MEMANTINE AND KETAMINE AS ANTI-MIGRAINE AGENTS (PODKAWA, ET AL, 2023)

The NMDA receptor antagonists memantine and ketamine as anti-migraine agents - Naunyn-Schmiedeberg’s Archives of Pharmacology
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors: memantine and ketamine might be beneficial in the therapy of this entity. Therefore, the purpose of this work is to present NMDA receptor antagonists, memantine and ketamine, as potential anti-migraine agents. We searched PubMed/MEDLINE, Embase, and clinical trials submitted to ClinicalTrials.gov to find publications describing eligible trials published between database inception and December 31, 2021. This comprehensive literature review summarizes data on the use of the NMDA receptor antagonists memantine and ketamine in the pharmacotherapy of migraine. Results from 20 previous and recent preclinical experiments are discussed and correlated with 19 clinical trials (including case series, open-label, and randomized placebo-controlled trials). For the purposes of this review, the authors hypothesized that the propagation of SD is a major mechanism in the pathophysiology of migraine. In several animal studies and in vitro studies, memantine and ketamine inhibited or reduced propagation of the SD. In addition, the results of clinical trials suggest that memantine or ketamine may be an effective treatment option for migraine. However, most studies on these agents lack control group. Although further clinical trials are needed, the results suggest that ketamine or memantine may be promising molecules for the treatment of severe migraine. Particular attention should be paid to people who have a treatment-resistant form of migraine with aura or have exhausted existing treatment options. For them, the drugs under discussion could represent an interesting alternative in the future.
Migraine is a debilitating disorder affecting females more frequently than males. There is some evidence that drugs targeting glutamate receptors: memantine and ketamine might be beneficial in the therapy of this entity. Therefore, the purpose of this work is to present NMDA receptor antagonists, memantine and ketamine, as potential anti-migraine agents.

KETAMINE AND THE CONSCIOUS MIND (1972)

It is a matter of opinion whether or not a chemically induced transcendental experience should be available to anyone who desires it, but to induce such a state when it is not requested by the patient is a different ethical problem. 

A PILOT RANDOMIZED CONTROLLED TRIAL OF KETAMINE IN BORDERLINE PERSONALITY DISORDER (2023)

A pilot randomized controlled trial of ketamine in Borderline Personality Disorder - Neuropsychopharmacology
Neuropsychopharmacology - A pilot randomized controlled trial of ketamine in Borderline Personality Disorder
Infusions were well tolerated in both groups. Dissociative symptoms during infusion were more intense with ketamine than midazolam (t(12.3) = 3.61, p = 0.01), but they resolved by 40 min after infusion in both groups. Post-infusion adverse events were at the expected low levels in both groups.

COMBINING KETAMINE AND PSYCHOTHERAPY FOR THE TREATMENT OF POSTTRAUMATIC STRESS DISORDER: A SYSTEMATIC REVIEW AND META-ANALYSIS (PHILIPP-MULLER, ET AL, 2023)

Combining Ketamine and Psychotherapy for the Treatment of Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis
J Clin Psychiatry 2023;84(2):22br14564 To cite: Philipp-Muller AE, Stephenson CJ, Moghimi E, et al. Combining ketamine and psychotherapy for the treatment
Pharmacologically enhanced psychotherapy is one potential means of prolonging ketamine’s effects, with the class of psychedelic medications (in which ketamine is included) yielding encouraging results

TIAM1-MEDIATED SYNAPTIC PLASTICITY UNDERLIES COMORBID DEPRESSION–LIKE AND KETAMINE ANTIDEPRESSANT–LIKE ACTIONS IN CHRONIC PAIN (RU, ET AL, 2023)

JCI - TIAM1-mediated synaptic plasticity underlies comorbid depression–like and ketamine antidepressant–like actions in chronic pain
stress and chronic pain appear to drive alterations in Tiam1-Rac1 signaling and synapse connectivity and function that are rescued by ketamine treatment, but the manner of change and the brain regions/neural circuits involved may differ.

TOWARD SYNERGIES OF KETAMINE AND PSYCHOTHERAPY (MATHAI, ET AL, 2022)

Toward Synergies of Ketamine and Psychotherapy - PubMed
Ketamine is a dissociative drug that has been used medically since the 1970s primarily as an anesthetic agent but also for various psychiatric applications. Anecdotal reports and clinical research suggest substantial potential for ketamine as a treatment in conjunction with psychological interventio …
Finally, it is valuable to recognize the similarities between ketamine and classic (serotonergic) psychedelics such as psilocybin and lysergic acid diethylamide (LSD), which produce overlapping subjective phenomena in spite of diverging pharmacological mechanisms of action (Bowdle et al., 1998Studerus et al., 2010). For classic psychedelics, it is well-established that a subset of psychoactive effects, often referred to as mystical-type effects and characterized by a sense of unity, predict greater therapeutic response across a variety of conditions such as depression, existential distress, and substance use disorders (Garcia-Romeu et al., 2014Griffiths et al., 2016Roseman et al., 2018). Interestingly, it has been hypothesized that the same mechanisms that drive the efficacy of these treatments may also be responsible for dose-dependent psychiatric risks, like that of psychosis (Haarsma et al., 2021). However, the relevant psychoactive effects of classic psychedelics appear to be optimized in careful experimental conditions that consider the benefit, safety, and tolerability of such (Johnson et al., 2008dos Santos et al., 2018). While similar optimization has not been pursued for ketamine, increasing research suggests that mystical- and peak-type experiences, such as measured by the Hood Mysticism Scale (HMS) and 11D-ASC questionnaire, increase the likelihood of various therapeutic benefits (Dakwar et al., 20142018Mollaahmetoglu et al., 2021Rothberg et al., 2021Sumner et al., 2021).

KETAMINE’S ROLE IN SPIRITUALITY: HOW ONE SYNTHETIC DRUG CATALYZES A NATURAL EXPERIENCE (WOODS, 2021)

The psychedelic effects associated with ketamine encourages a detachment from these thoughts processes— bringing forth a sense of intense and often overwhelming spiritual vulnerability for the patient. Therefore, an individual’s perception of pain may be significantly altered by ketamine because he or she is not experiencing typical, waking-reality thought processes but is instead experiencing unfamiliar, subconscious levels of thought. That is to say, these spiritual experiences are ordinarily invisible to us and are inaccessible using our normal states of consciousness (Strassman 54). Consequently, these spiritual-in-nature, ketamine variables may alter the patients’ response to various pain experiences, thus affecting their recovery options (Dedeli).

KETAMINE CAN BE PRODUCED BY POCHONIA CHLAMYDOSPORIA: AN OLD MOLECULE AND A NEW ANTHELMINTIC? (FERREIRA, ET AL, 2020)

Ketamine can be produced by Pochonia chlamydosporia: an old molecule and a new anthelmintic? - PubMed
The results presented here demonstrate the nematicidal activity of ketamine in vitro and in vivo, thus confirming the nematicidal potential of the molecule present in the fungus P. chlamydosporia may consist of a new method of controlling parasites.

“…we isolated and characterized molecules from the nematophagous fungus Pochonia chlamydosporia and tested these compounds on three nematodes: Caenorhabditis elegans; Ancylostoma ceylanicum; and Ascaris suum.”

INCREASED SPONTANEOUS MEG SIGNAL DIVERSITY FOR PSYCHOACTIVE DOSES OF KETAMINE, LSD AND PSILOCYBIN (SCHARTNER, ET AL, 2017)

Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin - Scientific Reports
Scientific Reports - Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin

“…WE FOUND A CLEAR INCREASE IN SIGNAL DIVERSITY FOR ALL THREE PSYCHEDELIC AGENTS AT THE GROUP LEVEL, WITH EFFECTS BEING STRONGEST FOR KET. THESE INCREASES WENT BEYOND THOSE EXPECTED FROM THE CHANGES TO THE FREQUENCY SPECTRUM.”

NEURAL MECHANISMS AND PSYCHOLOGY OF PSYCHEDELIC EGO DISSOLUTION (STOLIKER ET AL, 2022)

Surmising that the experience of ego dissolution exists at the center of the psychedelic experience and that its neural mechanisms may be close to the roots of the subject-object dichotomy may explain why phenomenological encounters with this experience can be intimate and fundamentally change self-identification and interactions with the world. Continued investigation of the neural mechanisms of ego dissolution and the dichotomy of separation between the self and the world may advance scientific understanding of sentience. The value of psychedelics may then, under appropriate conditions, be their power to catalyze meaningful philosophical and scientific understanding of the “u” (i.e., self) in the universe.


The safety and efficacy of psychedelic-assisted therapies are currently under investigation. No psychedelic-assisted therapy has been approved by the FDA or other regulatory authorities; no therapy works for everyone; and all therapies, even in clinical settings, carry risks.

The FDA does not regulate the practice of psychotherapy.

Get Ready for the Magic Mushroom Pill
The medical benefits of psychedelic drugs have gone from Age of Aquarius punchline to solid science, but the startups racing to market might still be getting ahead of themselves.
How a near-death experience could change the way you live
When Randy Schiefer was hospitalized with COVID-19, he wasn’t sure he would survive. Now, he looks back at that experience as the most important thing that has ever happened to him.
Peak-experience and the entheogenic use of cannabis in world religions
Abstract This paper demonstrates that cannabis can evoke “peak-experiences”—the name psychologist Abraham Maslow gave to fleeting moments of expanded perception indicative of self-transcendence—when used alongside more traditional religious practices such as meditation, fasting, contemplative prayer, and sacramental ritual. For that reason, religious seekers around the globe have deployed cannabis as a deliberate psychoactive to trigger the peak-experiences that stir feelings of ecstasy, wonder, and awe and resolve the “dichotomies, polarities, and conflicts of life.” As such, peak-experiences exemplify a form of spiritual revelation that has played a pivotal role in the history of religion, and because of its ability to elicit unitive consciousness at the heart of mystical insight, cannabis has been utilized as a mild entheogen across culture and tradition for millennia.

Can Psychedelic Therapy Offer a Sense of Peace for the Dying?
A CU Anschutz expert explains how dying patients describe existential distress and how psychedelic-assisted therapy could help fill a gap in care.
Frontiers | Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance
The efficacy of psychedelic-assisted therapies for mental disorders has been attributed to the lasting change from experiential avoidance to acceptance that…
Johns Hopkins researchers explore the link between psychedelics and consciousness
Psychedelic drugs, like psilocybin, an ingredient found in so-called magic mushrooms, have shown promise in treating a range of addictions and mental health disorders.
The Promise of Psychedelics for Health and Health Behaviors
Using psychedelics to improve health habits and chronic diseases may sound too good to be true. But early research is promising.
Frontiers | Behavioral Psychedelics: Integrating Mind and Behavior to Improve Health and Resilience
One of the most recent and potentially promising advancements in the health sciences has involved the attempted use of psychedelics for treating mental and b…
You Won’t Feel High After Watching This Video
Psychedelic therapy was supposed to treat her PTSD. Instead, it traumatized her even more.

Psychedelic healthcare: the next five years - PSYCH
Drug discovery and development is an extensive process, taking several years to progress through pre-clinical research and clinical trials.
Using Psychedelics to Heal from Sexual Trauma
Psychiatrists diagnosed me with so many different conditions after I was sexually assaulted that I don’t remember them all. What was wrong with me?
Psychedelic-Assisted Therapy with Transgender and Gender Diverse Individuals
Written by Jae Sevelius, Ph.D. MAPS Bulletin Spring 2019: Vol. 29, No. 1 Download this article. MDMA-assisted psychotherapy has demonstrated tremendous promise in the treatment of posttraumatic stress disorder (PTSD). Extreme disparities exist in rates of PTSD, with people of color and transgender (“trans”) and gender diverse people experiencing particularly high rates of trauma compared… Continue reading Psychedelic-Assisted Therapy with Transgender and Gender Diverse Individuals
The Midnight Gospel: Psychedelics and Escapism | Reality Sandwich
It seems Netflix has a show for just about anyone, from psychonauts to straight-edged people and everything in between. The Midnight Gospel, the brainchild of comedian Duncan Trussell and animator Pendleton Ward, takes audiences on the trippy hero’s journey of space podcaster Clancy Gilroy. Alongside audio derived from episodes of Duncan Trussell’s podcast, Clancy acts […]

The role of Indigenous knowledges in psychedelic science
This paper reflects on potential contributions from anthropology to the field of “psychedelic science.” Although the discipline’s beginnings went hand in hand with colonialism, it has made significant contributions to the understanding of Indigenous knowledge systems. Furthermore, recent calls to decolonize our theoretical frameworks and methodology, notably the “ontological turn,” open up the space for engaging meaningfully with Indigenous worldviews. At this critical juncture of the “psychedelic renaissance,” it is important to reflect on whether the current model is satisfactory and on ways to decolonize psychedelic science. What we need is a shift in paradigm, one that will acknowledge the validity of Indigenous worldviews as equal partners to scientific inquiry. Acknowledging the contributions of Indigenous knowledges to psychedelic science is necessary and needs to go hand in hand with attempts to revise biomedical models to be more inclusive in substantial ways. The paper does not argue for the abandonment of the scientific paradigm, rather for the abandonment of its privileged position. Decolonizing psychedelic science will require allowing multiple perspectives to coexist and contribute equally to our efforts going forward.
Frontiers | A Single Belief-Changing Psychedelic Experience Is Associated With Increased Attribution of Consciousness to Living and Non-living Entities
IntroductionAlthough the topic of consciousness is both mysterious and controversial, psychedelic drugs are popularly believed to provide unique insights int…

Frontiers | Unifying Theories of Psychedelic Drug Effects
How do psychedelic drugs produce their characteristic range of acute effects in perception, emotion, cognition, and sense of self? How do these effects relat…

THERAPEUTIC KETAMINE - LOWER ADDICTION POTENTIAL THAN PREVIOUSLY THOUGHT

Therapeutic use of ketamine may be safe, study suggests
Commonly used in medicine as an anesthetic, ketamine is also increasingly prescribed to relieve depressive symptoms. This very fast-acting psychotropic drug is particularly indicated for the treatment of patients resistant to conventional antidepressants.

PERCENTAGE OF HEAVY DRINKING DAYS FOLLOWING PSILOCYBIN-ASSISTED PSYCHOTHERAPY VS PLACEBO IN THE TREATMENT OF ADULT PATIENTS WITH ALCOHOL USE DISORDER (BOGUNSCHUTZ, ET AL, 2022)

Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder
This randomized clinical trial evaluates the combination of psychotherapy with psilocybin vs active placebo in patients with alcohol use disorder.

COMPARISON OF PSYCHEDELIC AND NEAR-DEATH OR OTHER NON-ORDINARY EXPERIENCES IN CHANGING ATTITUDES ABOUT DEATH AND DYING (SWEENEY, ET AL, 2022)

Comparison of psychedelic and near-death or other non-ordinary experiences in changing attitudes about death and dying
Both psychedelic drug experiences and near-death experiences can occasion changes in perspectives on death and dying, but there have been few direct comparisons of these phenomena. This study directly compared psychedelic occasioned and non-drug experiences which altered individuals’ beliefs about death. Individuals who reported an experience that altered their beliefs about death occasioned by either a psychedelic drug or a near-death or other non-ordinary experience completed an online survey. Circumstances of the experience, mystical and near-death subjective features, changes in attitudes about death, and other persisting effects were evaluated. The study sample (n = 3192) included five groups: non-drug near-death or other non-ordinary experiences (n = 933), and drug experiences occasioned by lysergic acid diethylamide (LSD) (n = 904), psilocybin (n = 766), ayahuasca (n = 282), or N,N-dimethyltryptamine (DMT) (n = 307). Analyses of differences in experiences were adjusted statistically for demographic differences between groups. Compared to the psychedelic groups, the non-drug group was more likely to report being unconscious, clinically dead, and that their life was in imminent danger. The groups were remarkably similar in the reported changes in death attitudes attributed to the experience, including a reduced fear of death and high ratings of positive persisting effects and personal meaning, spiritual significance, and psychological insight. Although both psychedelic and non-drug participants showed robust increases on standardized measures of mystical and near-death experiences, these measures were significantly greater in the psychedelic participants. Non-drug participants were more likely to rate their experiences as the single most meaningful of their lives. Comparing across psychedelic substances, ayahuasca and DMT groups tended report stronger and more positive enduring consequences of the experience than the psilocybin and LSD groups, which were largely indistinguishable. These data provide a detailed characterization and comparison of psychedelic occasioned and non-drug experiences that changed attitudes about death and suggest the importance of future prospective psychedelic administration studies.

PSYCHEDELIC DRUGS CHANGE STRUCTURE OF NEURONS

Psychedelic Drugs Change Structure of Neurons
A team of scientists at the University of California, Davis, is exploring how hallucinogenic drugs impact the structure and function of neurons — research that could lead to new treatments for depression, anxiety and related disorders.

PSYCHEDELICS AND MENTAL HEALTH: WHAT DOES THE SCIENCE SAY? (FORBES, 2022)

Psychedelics And Mental Health: What Does The Science Say?
Psychedelics And Mental Health: What Does The Science Say?

KETAMINE, PSILOCYBIN AND ECSTASY ARE COMING TO THE MEDICINE CABINET (THE ECONOMIST, 2022)

Ketamine, psilocybin and ecstasy are coming to the medicine cabinet
From expanding minds to healing brains

WHITE MATTER ALTERATIONS IN CHRONIC MDMA USE: EVIDENCE FROM DIFFUSION TENSOR IMAGING AND NEUROFILAMENT LIGHT CHAIN BLOOD LEVELS (ZIMMERMAN, ET AL, 2022)

White matter alterations in chronic MDMA use: Evidence from diffusion tensor imaging and neurofilament light chain blood levels - PubMed
3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”) is a serotonin- and noradrenaline-releasing substance, currently among the most widely used illicit substances worldwide. In animal studies, repeated exposure to MDMA has been associated with dendritic but also axonal degeneration in the brain. How …

TOWARDS AN UNDERSTANDING OF PSYCHEDELIC-INDUCED NEUROPLASTICITY (CALDER, ET AL, 2022)

Towards an understanding of psychedelic-induced neuroplasticity - Neuropsychopharmacology
Neuropsychopharmacology - Towards an understanding of psychedelic-induced neuroplasticity

PSYCHEDELIC INTEGRATION: AN ANALYSIS OF THE CONCEPT AND ITS PRACTICE (BATHJE, ET AL, 2020)

Psychedelic integration: An analysis of the concept and its practice - PubMed
The concept of integration has garnered increased attention in the past few years, despite a long history of only brief mention. Integration services are offered by therapists, coaches, and other practitioners, or may be self-guided. There are many definitions of psychedelic integration, and the ter …

PSYCHEDELIC-ASSISTED THERAPY AND PSYCHEDELIC SCIENCE: A REVIEW AND PERSPECTIVE ON OPPORTUNITIES IN NEUROSURGERY AND NEURO-ONCOLOGY (DANIEL, ET AL, 2023)

Psychedelic-Assisted Therapy and Psychedelic Science: A... : Neurosurgery
nd lysergic acid diethylamide and nonclassic psychedelics 3,4-methylenedioxymethamphetamine and ketamine are increasingly appreciated as neuroplastogens given their potential to fundamentally alter mood and behavior well beyond the time window of measurable exposure. Imaging studies with psychedelics are also helping advance our understanding of neural networks and connectomics. This resurgence in psychedelic science and psychedelic-assisted therapy has potential significance for the fields of neurosurgery and neuro-oncology and their diverse and challenging patients, many of whom continue to have mental health issues and poor quality of life despite receiving state-of-the-art care. In this study, we review recent and ongoing clinical trials, the set and setting model of psychedelic-assisted therapy, potential risks and adverse events, proposed mechanisms of action, and provide a perspective on how the safe and evidence-based use of psychedelics could potentially benefit many patients, including those with brain tumors, pain syndromes, ruminative disorders, stroke, SAH, TBI, and movement disorders. By leveraging psychedelics’ neuroplastic potential to rehabilitate the mind and brain, novel treatments may be possible for many of these patient populations, in some instances working synergistically with current treatments and in some using subpsychedelic doses that do not require mind-altering effects for efficacy. This review aims to encourage broader multidisciplinary collaboration across the neurosciences to explore and help realize the transdiagnostic healing potential of psychedelics.…

CLASSICAL AND NON-CLASSICAL PSYCHEDELIC DRUGS INDUCE COMMON NETWORK CHANGES IN HUMAN CORTEX (DAI, Et AL, 2023)

Classical and non-classical psychedelic drugs induce common network changes in human cortex - PubMed
The neurobiology of the psychedelic experience is not fully understood. Identifying common brain network changes induced by both classical (i.e., acting at the 5-HT<sub>2</sub> receptor) and non-classical psychedelics would provide mechanistic insight into state-specific characteristics. We analyzed …

MULTI-MEDIA〰️


ONGOING RESEARCH

AMERICAN PSYCHOLOGICAL ASSOCIATION (APA) SAYS “RESEARCH CONFIRMS THE THERAPEUTIC POTENTIAL OF #MDMA #KETAMINE, AND #PSILOCYBIN TO HELP PEOPLE WITH TREATMENT-RESISTANT MENTAL HEALTH CONDITIONS” (2024)

“If we rely on antidepressants for treatment, it can take several weeks before people experience amelioration of symptoms, if at all,” said Nora Volkow, MD, director of the National Institute on Drug Abuse. “Psychedelics may offer the opportunity to get a very fast and lasting response, and with some conditions, this could be lifesaving.” The latest research findings are also uncovering the potential neurobiological mechanisms that might make it possible for these controlled substances to produce mental health benefits.”

Jun 26, 2024ketamine assisted therapyketamine therapypalm springs therapiststelehealth therapyonline therapypsychedelic therapy onlineketamine assisted therapy onlinepsychedelic mental healthCONTINUING EDUCATION "MEDICAL PSYCHIATRY: COMPREHENSIVE UPDATE” HARVARD UNIVERSITY Jun 24, 2024KETAMINE BY MOUTH - ONGOING REVIEW OF THE LITERATURE

The Psychedelic Institute of Mental Health & Family Therapyoffers psychedelic-assisted psychotherapy in colaboration with the medical clinician who prescribes the medication, consultation, lit review, and clinical practicum training. Psychotherapy Telehealth CA, NY, UT, VT, Licensed Marriage and Family Therapist supervised. Become a Member!

Jun 20, 2024gendertherapistname changegender markertranssexualtransgendersrlpsylvia rivera law projectnycnew yorkketamineketamine-assisted therapyutahvermontnew yorkcaliforniapalm springsjoshua treeketamine therapistpsychedelic therapistpsychedelic therapypsychedelic researcherketamine researchAT-HOME KETAMINE ASSISTS PSYCHOTHERAPY IN-PERSON OR VIA TELEHEALTH

Licensed psychotherapists have offered telehealth before the pandemic. Some licensed psychotherapists specialize in psychedelic-assisted psychotherapy where we can sit with you in person in your home, in our office, or remotely via video conferencing. Out-of-clinic ketamine has been prescribed since before the pandemic, largely made by compounding pharmacies, for pain management and in psychiatry-- check out "Ketamine for Depression", (Snyder, 2015), and "The Ketamine Papers" (Wolfson, et al, 2016).

At-home ketamine from companies that are price-gouging for a 15 minute medical visit to get a prescription for a generic drug that's been used in millions of humans and animals since the 1960's in various settings-- and leaving you to it, is NOT the same as ketamine-assisted psychotherapy done in an office, at home, or any other setting standard in our field. This includes telehealth. If the person working with the client before during and after is with them physically in person, and something goes wrong, we are going to call 911, the same as we would if they were in an office. Additionally, some telehealth clinicians require an adult sober-sitter on premises with the client, to physically check on a client if something seems out-of-the-ordinary. That is in addition to the mental health specialist being remotely available the entire time the client is under the acute effects of the medicine.

Mar 5, 2024at home ketamineketamine-assisted psychotherapyketamine-assisted therapyketamine iv therapyketamine infusionsublingual ketamineketamine lozengeketamine therapistsEVENT: MARCH 14TH, 2024– INTRODUCTION TO END OF LIFE PSYCHEDELIC CARE

Ketamine is legally available throughout North America and has demonstrated remarkable efficacy in treating anxiety and depression. The presentation will highlight how ketamine therapy, whether in a clinical setting or through at-home administration, offers relief and restores hope to patients. We will cover the benefits provided by in-clinic sessions, as well as the empowerment clients experience with at-home ketamine therapy when supported by trained professionals.

Mar 5, 2024end of lifepsychedelicsketamine therapyIAI.TV : THE REALITY OF THE MYSTICAL EXPERIENCE

The reality of the mystical experience | Ricky Williamson
What is the role of spiritual experience in our lives? Does it point to something beyond the everyday material world, or is it a mere hallucination? If we are to be true empiricists, we must take mystical experiences seriously, argues Ricky Williamson.

As is well documented, during the mystical experience, the subject-object distinction breaks down. The idea that ‘I am in here’ and ‘the world is out here’ disappears. For my consciousness of the world takes up the very same space as that which I call my mind. There is, in perception, no ‘inside’ the mind and ‘outside’ to the world. Look around you. All you can see is the outside! All you see is the room, and the window, and the sky. You do not see the interior of your mind – unless the world itself makes up that interior. Douglas Harding’s book ‘On Having No Head’, explains this idea very simply and allows for the clearest perception of the non-duality of the mystical experience. But Heidegger’s ‘being-in-the-world’ and Sartre’s ‘being and nothingness’ approach the same idea. And yet, while the mystical experience allows us to come to this truth that there really is no subject-object distinction, no ‘me vs the world’, this truth still holds for everyday reality too.

Oct 9, 2023ketaminemystical experienceSCIENTISTS SAY A MIND-BENDING RHYTHM IN THE BRAIN CAN ACT LIKE KETAMINE

"It was like pointing a telescope at a new part of the sky," Deisseroth says. "And something really unexpected jumped out at us."

Sep 28, 2023ketaminedissociationdepressionCHACRUNA PUBLISHES ARTICLE CHALLENGING DEA AYAHUASCA REPORT

Health professionals need to recognize the historical and cultural values of these plant medicines for Indigenous and traditional populations. These groups have been using ayahuasca and other plant medicines for centuries as part of their traditional healing systems. It is important to understand that we are dealing with traditions that do not abide by the concepts of Western healing, and that have their own logic and value. These practices must be recognized on their own terms. It is not a matter of opposing traditional healing systems and Western medicine, but of recognizing the uniqueness and importance of the former. In fact, it is widely known that in order to develop research and policy on ayahuasca it is crucial to consider the gathered knowledge and the experience of the groups that have been taking ayahuasca for centuries – Bia Labate, PhD, Executive Director, Chacruna Institute

Jun 12, 2023ayahauscalegalizationcriminalizationmedicinesacramentNATURAL HISTORY MUSEUM-- BEYOND GENDER: INDIGENOUS PERSPECTIVES- A LIMITED SERIES ON SOME OF THE WORLD'S THIRD GENDER INDIGENOUS PEOPLEApr 13, 2023gender affirming therapistgender-affirming therapygender around the worldgender is a constructKETAMINE PSYCHEDELIC EXPERIENCE RELATED TO OUTCOME OF TREATMENT (PSYCHIATRIC TIMES, 2018)

A cautious approach also seems imperative given evidence that ketamine demonstrates agonist activity at μ-opioid receptors and dopaminergic effects that may confer acute relief of depressive symptoms but also greater risk for positive drug reinforcement and dependence. With further insight into psychological responses mediated by ketamine, it may be that a therapy-based framework for ketamine administration optimizes treatment efficacy and sustainability, while also minimizing unnecessary drug exposure, adverse effects of chronic use, and dependency risk.

Mar 1, 2023

Cahuilla Territory, aka Palm Springs, Coachella Valley, California

 

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