Ketamine Lit Review & Bibliography

An ongoing selected bibliography and review of the literature related to ketamine

Further Selected Bibliography

Ko K, Knight G, Rucker JJ, Cleare AJ. Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic

Review. Front Psychiatry. 2022;13:917199. Published 2022 Jul 12. doi:10.3389/fpsyt.2022.917199

Lowe H, Toyang N, Steele B, et al. Psychedelics: Alternative and Potential Therapeutic Options for Treating Mood and Anxiety

Disorders. Molecules. 2022;27(8):2520. Published 2022 Apr 14. doi:10.3390/molecules27082520

Reiff CM, Richman EE, Nemeroff CB, et al. Psychedelics and Psychedelic-Assisted Psychotherapy. Am J Psychiatry.

2020;177(5):391-410. doi:10.1176/appi.ajp.2019.19010035

Ioannis Alex Malidelis, MD Andrew Hunt, MD Awais Aftab, MD Medication-Assisted Psychotherapy: The Past and Future of

Psychiatry January 12, 2024 Psychiatric Times Vol 41, Issue 1

Yehuda R, Lehrner A Psychedelic Therapy—A New Paradigm of Care for Mental Health. JAMA. 2023;330(9):813–814.

doi:10.1001/jama.2023.12900

Greenway KT, Garel N, Jerome L, Feduccia AA. Integrating psychotherapy and psychopharmacology: psychedelic-assisted

psychotherapy and other combined treatments. Expert Rev Clin Pharmacol. 2020;13(6):655-670.

doi:10.1080/17512433.2020.1772054

Marguilho M, Figueiredo I, Castro-Rodrigues P. A unified model of ketamine's dissociative and psychedelic properties. J

Psychopharmacol. 2023;37(1):14-32. doi:10.1177/02698811221140011

E. Khorramzadeh, AO, & Lotfy, The Use of Ketamine in Psychiatry,Psychosomatics,Volume 14, Issue 6,2973,Pages 344-346,

ISSN 0033-3182,https://doi.org/10.1016/S0033-3182(73)71306-2.

Wolfson, P, & Hartelius, G. The ketamine papers. Santa Cruz, CA: MAPS. 2016

Krupitsky EM, Grinenko AY. Ketamine psychedelic therapy (KPT): a review of the results of ten years of research. J

Psychoactive Drugs. 1997;29(2):165-183. doi:10.1080/02791072.1997.10400185)

Kolp, E, Friedman, H ., Krupitsky, E, et al Ketamine psychedelic psychotherapy: Focus on its pharmacology, phenomenology,

and clinical applications. International Journal of Transpersonal Studies, 33(2), 84–140.. International Journal of Transpersonal

Studies, 33 (2). http://dx.doi.org/10.24972/ijts.2014.33.2.84

Carhart-Harris, R, Roseman, E. Haijen, D et al 2018, July. Psychedelics and the essential importance of context. Journal of

Psychopharmacology 32 (7):725–31. Epub 2018 Feb 15. doi:10.1177/0269881118754710.

Walsh Z, Mollaahmetoglu OM, Rootman J, et al. Ketamine for the treatment of mental health and substance use disorders:

comprehensive systematic review. BJPsych Open, 8(1), e19. 10.1192/bjo.2021.1061.

Johnson & Johnson Press Release. Esketamine Receives Breakthrough Therapy Designation from U.S. Food and Drug

Administration for Major Depressive Disorder with Imminent Risk for Suicide. Available at: https://www.jnj.com/media-center/

press-releases/esketamine-recieves-breakthrough-therapy-designation-from-us-food-and-drug-administration-for-major-

depressive-disorder-with-imminent-risk-of-suicide. Accessed January 16, 2024.

Dore J, Turnipseed B, Dwyer S, et al. Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and

Outcomes in Three Large Practices Administering Ketamine with Psychotherapy. J Psychoactive Drugs. 2019;51(2):189-198.

doi:10.1080/02791072.2019.1587556

Meshkat S, Haikazian S, Di Vincenzo JD, et al. Oral ketamine for depression: An updated systematic review. World J Biol

Psychiatry. 2023;24(7):545-557. doi:10.1080/15622975.2023.2169349

Swainson, J, Klassen, LJ, Brennan, S., et al. Non-parenteral Ketamine for Depression: A Practical Discussion on Addiction

Potential and Recommendations for Judicious Prescribing. CNS drugs, 36(3), 239–251. 2022.https://doi.org/10.1007/

s40263-022-00897-2

Kheirkhah F, Tayyebi G, Rabiee SM, et al Efficacy of different doses of ketamine as a bolus in major depressive disorder.

Caspian J Intern Med. 2018;9(3):220-227. doi:10.22088/cjim.9.3.220

Drozdz SJ, Goel A, McGarr MW, et al. Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature. J

Pain Res. 2022;15:1691-1706. Published 2022 Jun 15. doi:10.2147/JPR.S360733An Expert Informed Introduction to the Elements of Psychedelic-Assisted Therapy, Brainfutures, 2022.

Mian MN, Altman BR, Low F, Earleywine M. Development of the Protective Strategies for Psychedelics Scale: A novel

inventory to assess safety strategies in the context of psychedelics. J Psychopharmacol. Published online December 4, 2023.

doi:10.1177/02698811231214060

Butler M, Jelen L, Rucker J. Expectancy in placebo-controlled trials of psychedelics: if so, so what?. Psychopharmacology

(Berl). 2022;239(10):3047-3055. doi:10.1007/s00213-022-06221-6

Syed, OA, Tsang, B Managing expectations with psychedelic microdosing. npj Mental Health Res 2, 19 2023. https://doi.org/

10.1038/s44184-023-00044-9

Kaertner LS, Steinborn MB, Kettner H, et al. Positive expectations predict improved mental-health outcomes linked to

psychedelic microdosing. Sci Rep. 2021;11(1):1941. Published 2021 Jan 21. doi:10.1038/s41598-021-81446-7

Lii, TR, Smith, AE, Flohr, JR et al. Randomized trial of ketamine masked by surgical anesthesia in patients with depression.

Nat. Mental Health 1, 876–886 2023. https://doi.org/10.1038/s44220-023-00140-x

Earleywine, M , Altman, BR & De Leo, J Cognitive Behavioral Therapy, Ketamine, and Combination Treatment for

Depression: Impressions of Credibility in Participants with Self-Reported Depressive Symptoms, Journal of Psychoactive Drugs,

54:1, 70-80, 2022 DOI: 10.1080/02791072.2021.1912863

Murphy R, Kettner H, Zeifman R, et al. Therapeutic Alliance and Rapport Modulate Responses to Psilocybin Assisted Therapy

for Depression. Front Pharmacol. 2022;12:788155. Published 2022 Mar 31. doi:10.3389/fphar.2021.788155

Zhao S, Sampson S, Xia J, Jayaram MB. Psychoeducation (brief) for people with serious mental illness. Cochrane Database of

Systematic Reviews 2015, Issue 4. Art. No.: CD010823. DOI: 10.1002/14651858.CD010823.pub2. Accessed 16 January 2024.

Barrett FS, Robbins H, Smooke D, Bet al. Qualitative and Quantitative Features of Music Reported to Support Peak Mystical

Experiences during Psychedelic Therapy Sessions. Front Psychol. 2017;8:1238. Published 2017 Jul 25. doi:10.3389/

fpsyg.2017.01238

Leary, T, Mettzner, R, & Alpert R, The psychedelic experience; a manual based on the Tibetan book of the dead New York

University Books; 1964.

Hartogsohn I. Constructing drug effects: A history of set and setting. Drug Science, Policy and Law. 2017;3.

doi:10.1177/2050324516683325

Hassan K, Struthers WM, Sankarabhotla A et al. Safety, effectiveness and tolerability of sublingual ketamine in depression and

anxiety: A retrospective study of off-label, at-home use. Front. Psychiatry 13:992624. 2022 doi: 10.3389/fpsyt.2022.992624

Hull TD, Malgaroli M, Gazzaley A, et al. At-home, sublingual ketamine telehealth is a safe and effective treatment for

moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial. Journal of Affective

Disorders. 2022 Oct 1;314:59-67. https://doi.org/10.1016/j.jad.2022.07.004

Swainson, J, Klassen, LJ, Brennan, S, . Non-parenteral Ketamine for Depression: A Practical Discussion on Addiction Potential

and Recommendations for Judicious Prescribing. CNS drugs, 36(3), 239–251. 2022. https://doi.org/10.1007/s40263-022-00897-2

Benini F, Congedi S, Giacomelli L, et al, Refractory symptoms in paediatric palliative care: can ketamine help?. Drugs

Context. 2021;10:2021-2-5. Published 2021 May 19. doi:10.7573/dic.2021-2-5

Goldman N, Frankenthaler M, Klepacz L. The Efficacy of Ketamine in the Palliative Care Setting: A Comprehensive Review

of the Literature. J Palliat Med. 2019;22(9):1154-1161. doi:10.1089/jpm.2018.0627

Soto E, Stewart DR, Mannes AJ, et al. Oral ketamine in the palliative care setting: a review of the literature and case report of a

patient with neurofibromatosis type 1 and glomus tumor-associated complex regional pain syndrome. Am J Hosp Palliat Care.

2012;29(4):308-317. doi:10.1177/1049909111416345

Mediano PAM, Rosas FE, Timmermann C, et al. Effects of External Stimulation on Psychedelic State Neurodynamics. ACS

Chem Neurosci. Published online January 12, 2024. doi:10.1021/acschemneuro.3c00289

Kolp, E, Friedman, H ., Krupitsky, E, et al Ketamine psychedelic psychotherapy: Focus on its pharmacology, phenomenology,

and clinical applications. International Journal of Transpersonal Studies, 33(2), 84–140.. International Journal of Transpersonal

Studies, 33 (2). http://dx.doi.org/10.24972/ijts.2014.33.2.84

Swainson J, Khullar A. Sublingual ketamine: an option for increasing accessibility of ketamine treatments for depression? J

Clin Psychiatry 2020; 81(1): 19lr13146.

Jansen, KLR The Ketamine Model of the Near-Death Experience: A Central Role for the N-Methyl-D-Aspartate Receptor.

Journal of Near-Death Studies 16, 5–26 1997. https://doi.org/10.1023/A:1025055109480

Niciu MJ, Shovestul BJ, Jaso BA, et al. Features of dissociation differentially predict antidepressant response to ketamine in

treatment-resistant depression. J Affect Disord. 2018;232:310-315. doi:10.1016/j.jad.2018.02.049

Luckenbaugh DA, Niciu MJ, Ionescu DF, et al. Do the dissociative side effects of ketamine mediate its antidepressant effects?.

J Affect Disord. 2014;159:56-61. doi:10.1016/j.jad.2014.02.017

Ko K, Knight G, Rucker JJ, Cleare AJ. Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic

Review. Front Psychiatry. 2022;13:917199. Published 2022 Jul 12. doi:10.3389/fpsyt.2022.917199

Hack, L.M., Zhang, X., Heifets, B.D. et al. Ketamine’s acute effects on negative brain states are mediated through distinct

altered states of consciousness in humans. Nat Commun 14, 6631 2023. https://doi.org/10.1038/s41467-023-42141-5

Romand R, Ehret G. Neuro-functional modeling of near-death experiences in contexts of altered states of consciousness. Front

Psychol. 2023;13:846159. Published 2023 Jan 18. doi:10.3389/fpsyg.2022.846159

Timmermann C, Roseman L, Williams L, et al DMT Models the Near-Death Experience. Front. Psychol. 9:1424. 2018 doi:

10.3389/fpsyg.2018.01424

Mathai DS, Mora V, Garcia-Romeu A. Toward Synergies of Ketamine and Psychotherapy. Front Psychol. 2022;13:868103.

Published 2022 Mar 25. doi:10.3389/fpsyg.2022.868103

Kolp, E., Friedman, H. L., Krupitsky, E., et al (2014). Ketamine psychedelic psychotherapy: Focus on its pharmacology,

phenomenology, and clinical applications. International Journal of Transpersonal Studies, 33(2), 84–140.. International Journal of

Transpersonal Studies, 33 (2). http://dx.doi.org/10.24972/ijts.2014.33.2.84

Pahnke, WN, & Richards, WA. Implications of LSD and Experimental Mysticism. Journal of Religion and Health, 5(3), 175–

208.1996 .http://www.jstor.org/stable/27504799

Griffiths RR, Johnson MW, Richards WA, Richards BD, McCann U, Jesse R. Psilocybin occasioned mystical-type experiences:

immediate and persisting dose-related effects. Psychopharmacology (Berl). 2011;218(4):649-665. doi:10.1007/

s00213-011-2358-5

Roseman, L., Nutt, D.J., & Carhart-Harris, R.L. (2018). Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy

of Psilocybin for Treatment-Resistant Depression. Frontiers in Pharmacology, 8.

Dai R, Larkin TE, Huang Z, et al. Classical and non-classical psychedelic drugs induce common network changes in human

cortex. Neuroimage. 2023;273:120097. doi:10.1016/j.neuroimage.2023.120097

Alexander, L, Hawkins, PCT, Evans, JW et al. Preliminary evidence that ketamine alters anterior cingulate resting-state

functional connectivity in depressed individuals. Transl Psychiatry 13, 371 (2023). https://doi.org/10.1038/s41398-023-02674-1

Stoliker D., Novelli L., et al, Neural Mechanisms of Resting-State Networks and the Amygdala underlying the Cognitive and

Emotional Effects of Psilocybin, Biological Psychiatry (2024), doi: https://doi.org/10.1016/ j.biopsych.2024.01.002.

Scheidegger M, Henning A, Walter M, et al. Ketamine administration reduces amygdalo-hippocampal reactivity to emotional

stimulation. Hum Brain Mapp. 2016;37(5):1941-1952. doi:10.1002/hbm.23148

Bathje GJ, Majeski E and Kudowor M Psychedelic integration: An analysis of the concept and its practice. Front. Psychol.

13:824077. 2022. doi: 10.3389/fpsyg.2022.824077

Aixalà, M. Psychedelic integration: Psychotherapy for non-ordinary states of consciousness. Synergetic Press. 2022

Frymann T, Whitney S, Yaden DB and Lipson J (2022) The Psychedelic Integration Scales: Tools for Measuring Psychedelic

Integration Behaviors and Experiences. Front. Psychol. 13:863247. 2022. doi: 10.3389/fpsyg.2022.863247

Dunlop BW, Rajendra JK, Craighead WE, et al. Functional connectivity of the subcallosal cingulate cortex and differential

outcomes to treatment with cognitive-behavioral therapy or antidepressant medication for major depressive disorder. Am J

Psychiatry. 2017;174:533–45.

Kumar V, Sattar Y, Bseiso A, et al. The Effectiveness of Internet-Based Cognitive Behavioral Therapy in Treatment of

Psychiatric Disorders. Cureus. 2017;9(8):e1626. Published 2017 Aug 29. doi:10.7759/cureus.1626

Yaden DB, Earp D, Graziosi M, et al. Psychedelics and Psychotherapy: Cognitive-Behavioral Approaches as Default. Front

Psychol. 2022;13:873279. Published 2022 May 23. doi:10.3389/fpsyg.2022.873279

Wilkinson ST, Rhee TG, Joormann J, et al. Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in

Treatment-Resistant Depression: A Randomized Clinical Trial. Psychother Psychosom. 2021;90(5):318-327.

doi:10.1159/000517074

Davis AK, Barrett FS, Griffiths RR. Psychological flexibility mediates the relations between acute psychedelic effects and

subjective decreases in depression and anxiety. J Contextual Behav Sci. 2020;15:39-45. doi:10.1016/j.jcbs.2019.11.004

Wolff M, Evens R, Mertens LJ, et al Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy

Promotes Acceptance. Front. Psychiatry 11:5. 2020 doi: 10.3389/fpsyt.2020.00005

Ellis, A The road to tolerance: The philosophy of rational emotive behavior therapy. Prometheus Books. 2004

Rosner, R, Albert Ellis' rational-emotive behavior therapy. Adolescent Psychiatry, 1(1), 82–87. 2011 https://doi.org/

10.2174/2210676611101010082

SmartRecovery.org Accessed January 16, 2024.https://smartrecovery.org

Newby, J, Mason, E,Kladnistki , Net al. Integrating internet CBT into clinical practice: a practical guide for clinicians, Clinical

Psychologist, 25:2, 164-178,2021. DOI: 10.1080/13284207.2020.1843968

González D, Aixalà MB, Neimeyer RA, Cantillo J, Nicolson D, Farré M. Restorative Retelling for Processing Psychedelic

Experiences: Rationale and Case Study of Complicated Grief. Front Psychol. 2022;13:832879. Published 2022 May 3.

doi:10.3389/fpsyg.2022.832879

William E. Rosa, Zachary Sager, Megan Miller, et al.Top Ten Tips Palliative Care Clinicians Should Know About Psychedelic-

Assisted Therapy in the Context of Serious Illness.Journal of Palliative Medicine.Aug 2022.1273-1281.http://doi.org/10.1089/

jpm.2022.0036

An Expert Informed Introduction to the Elements of Psychedelic-Assisted Therapy, Brainfutures, 2022.

Phelps, J Developing Guidelines and Competencies for the Training of Psychedelic Therapists Journal of Humanistic

Psychology, 2017, 1–38 DOI: 10.1177/0022167817711304

Delli Colli, C., Chiarotti, F., Campolongo, P. et al. Towards a network-based operationalization of plasticity for predicting the

transition from depression to mental health. Nat. Mental Health (2024). https://doi.org/10.1038/s44220-023-00192-z

Hyde, S Ketamine and depression. Xlibris. 2015

Wolfson, P, & Hartelius, G editors.. The Ketamine Papers. MAPS. 2016

Breitbart W. Existential isolation. Palliat Support Care. 2017;15(4):403-404. doi:10.1017/S1478951517000621