investigaciones sobre ketamina
En Foco: Un viaje largo y extraño: tratamiento con ketamina en psiquiatría (Nutt, et al, 2025)
"El primer trabajo clínico con ketamina en trastornos psiquiátricos comenzó en los años setenta con los médicos que utilizaban los efectos psicoactivos en pacientes psiquiátricos con beneficios terapéuticos."
ketamine
Spotlight: A long, strange trip: Ketamine treatment in psychiatry (Nutt, et al, 2025)
"...mystical experiences were strongly related to immediate and sustained psychiatric benefits at the group level and on an individual, session-by-session basis across the six doses, providing mechanistic support for ketamine-psychotherapy pairings."
ketamine
Spotlight: Rapid-acting NMDA and GABAergic Modulators in Mood Disorders: From Synaptic Mechanisms to Clinical Practice (Serretti, 2025)
"Depression is increasingly conceptualized as a disorder of impaired synaptic plasticity and excitation-inhibition imbalance within corticolimbic circuits. Ketamine, brexanolone, zuranolone, offer complementary approaches to restore circuit function."
ketamine
Spotlight: Personality profiles and trauma history in ketamine therapy for mood and anxiety disorders: A latent profile analysis of short-term outcomes (Gregoire, et al, 2025)
"Personality traits relate to baseline mental health severity but not short-term response to ketamine. Trauma history may predict greater benefit from treatment."
ketamine
Spotlight: Changing your mind: neuroplastic mechanisms underlying the therapeutic effect of psychedelics in depression, PTSD, and addiction (Palhas, et al, 2025)
"Serotonergic psychedelics & ketamine appear to share common cellular mechanisms. They both recruit glutamatergic neurons to stimulate BDNF-trKB signaling, promoting synaptogenesis via the mTOR pathway. These changes may explain their efficacy in depression, anxiety, PTSD, & addiction."
Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression
How does ketamine affect psychotherapy?
Studies suggest that human support is a factor in ketamine psychedelic therapy
salience network
Spotlight: Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression (Taraku, et al, 2025)
"findings suggest ketamine modulates brain network dynamics which may normalize dynamic patterns seen in TRD at baseline toward patterns seen in controls. Changes in Salience Network state dynamics may correspond to improvements in ruminative symptoms following ketamine therapy."
ketamine
Spotlight: Intermittent ketamine and neuromodulation treatment evoke synergistic antidepressant-relevant action (Brown, et al, 2025)
"The rapid response that can be observed following ketamine treatment has reconceptualized how pharmacotherapy can treat depression. One subanesthetic infusion can alleviate symptoms within hours; however, sustained relief also requires multiple doses. "
lsd
Spotlight: LSD: Mechanisms and relevance to the treatment of depression (Bouloufa, et al, 2025)
"Psychedelics may be a potential alternative therapy for treatment-resistant depression. LSD has a complex mode of action which is not yet fully understood.
Low doses of LSD can drastically increase brain plasticity."
ayahausca
Spotlight: Resilience and Brain Changes in Long-Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition (Ramos, et al, 2025)
"results suggest that long-term Ayahuasca use may be linked to lasting changes in emotional regulation and brain function, potentially supporting psychological well-being."
ketamine
Spotlight: Efficacy and safety of ketamine maintenance therapy in treatment-resistant depression: A systematic review of treatment protocols and clinical outcomes (Al-Garni, et al, 2025)
"Concurrent psychotherapy improved treatment maintenance. Adverse events were generally mild to moderate... Ketamine maintenance therapy shows promise as a treatment option for TRD, with regular dosing schedules and early intervention associated with optimal outcomes."
counseling in uruguay
Spotlight: Psychedelic Therapy for Digital Nomads & Ex-Pats | Uruguay
Online access to psychedelic mental health specialists can be an important part of integrating your experiences and building a sense of community that can be so difficult to find when living abroad
ketamine
Spotlight: Ketamine Assisted Therapy Outcomes for First-Responders with Comorbid Mental Health Diagnoses (Tsang, et al, 2025)
"KAT may provide meaningful benefits beyond symptom reduction."
ketamine
Spotlight: Oral ketamine for the treatment of major depressive and bipolar disorder, a randomized controlled trial and meta-analysis (Silberbauer, et al, 2025)
Treatment was well-tolerated, with no serious adverse events reported...in a total of 592 patients, meta-analysis of randomized controlled trials on oral ketamine treatment demonstrated its antidepressant efficacy with a Number Needed to Treat = 4.89 for response and a NNT = 9.16 for remission.
ketamina
En Foco: Psicoterapia Asistida con Ketamina & Apoyo para la reducción de daños en contextos psicodélicos
Más de 60 años de investigación con ketamina respaldan los beneficios de la ketamina demostrando que es una opción segura, eficaz y replicable en el tratamiento de varios trastornos de salud mental, especialmente cuando se la combina con terapia cognitivo-conductual
Spotlight: Exploring the potential of psychedelic-assisted psychotherapy for moral injury: A scoping review (Kerkova, et al, 2025)
"Studies reported rapid, increasing, sustained self-compassion over time, alongside increases in self-forgiveness & self-acceptance, reduction in demoralization, decreased drinking scores."
