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# Exploring the Therapeutic Potential of Ketamine and Psilocybin in Comparison to Current Treatment Regimens for Treatment-Resistant Depression, Mood Disorders, and Post-traumatic Stress Disorder in the Pediatric Population (Hughes, et al, 2025)
- URL: https://psychedelicmentalhealth.net/therapeutic-potential-of-ketamine-and-psilocybin-in-comparison-to-current-treatment-regimens-for-treatment-resistant-depression-mood-disorders-and-post-traumatic-stress/
- Published: 2025-09-19T12:12:13.000Z
- Updated: 2025-09-19T12:15:19.000Z
- Description: "Ketamine's use for pediatric TRD demonstrated rapid-onset relief for signs and symptoms of depression in children and adolescents, and psilocybin also decreased symptoms in patients with longstanding or refractory depression. Ketamine has been well tolerated and exhibited symptom improvements"
- Author: Michael DeMarco, PhD
- Tags: ketamine, pediatric, psilocybin, pediatric depression, depression treatment, ketamine-assisted-psychotherapy, ketamine therapy, ptsd, ketamine for ptsd, ketamine for depression, ketamine research, psychedelic research, is ketamine a psychedelic

[Exploring the Therapeutic Potential of Ketamine and Psilocybin in Comparison to Current Treatment Regimens for Treatment-Resistant Depression, Mood Disorders, and Post-traumatic Stress Disorder in the Pediatric Population: A Narrative Review - PubMedThe stresses of the Coronavirus Disease of 2019 (COVID-19) pandemic highlighted the burden of psychiatric disorders within the pediatric population, revealing a pre-existing need for rapid-onset therapies that have since driven efforts to expand effective therapeutic interventions. In this narrative …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-106.png)PubMedBrett Hughes![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-105.jpg)](https://pubmed.ncbi.nlm.nih.gov/40970030/)

(2025): "Ketamine has been well tolerated & exhibited symptom improvements for youth w/ mood disorders (anxiety & bipolar depression)..."