> ## Content Index > Fetch the complete content index at: https://psychedelicmentalhealth.net/llms.txt > Use this file to discover other available public pages before exploring further. # Spotlight: "Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study" (Singh, et al, 2025) - URL: https://psychedelicmentalhealth.net/spotlight-long-term-outcomes-in-patients-with-treatment-refractory-depression-receiving-intravenous-ketamine-and-intranasal-esketamine-an-observational-study-singh-et-al-2025/ - Published: 2025-08-06T20:50:34.000Z - Updated: 2025-08-06T20:50:34.000Z - Description: Observational study provides evidence regarding longer durability of generic IV ketamine compared to intranasal esketamine (Spravato). - Author: Michael DeMarco, PhD - Tags: iv ketamine, depression, ketamine therapy [Long-Term Outcomes in Patients With Treatment-Refractory Depression Receiving Intravenous Ketamine and Intranasal Esketamine: An Observational Study - PubMedObjective: This study examines the durability (defined as time between treatments) of intravenous ketamine (IV-KET) and intranasal esketamine (IN-ESKET) for treatment-resistant depression (TRD), in a real-world clinical setting with repeated ketamine/esketamine maintenance therapy. Methods …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-35.png)PubMedBalwinder Singh![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-34.jpg)](https://pubmed.ncbi.nlm.nih.gov/40767785/) Resultados a largo plazo en pacientes con depresión refractaria del tratamiento Recibiendo ketamina intravenosa y esketamina intranasal: Estudio observacional (Singh, et al, 2025) El estudio observacional proporciona pruebas de una durabilidad más larga de la ketamina intravenosa genérica en comparación con la esketamina intranasal (Spravato).