> ## Content Index > Fetch the complete content index at: https://psychedelicmentalhealth.net/llms.txt > Use this file to discover other available public pages before exploring further. # Spotlight: Ketamine to enhance methadone treatment retention in patients with opioid use disorder and co-morbid depression (Manza, et al, 2025) - URL: https://psychedelicmentalhealth.net/spotlight-ketamine-to-enhance-methadone-treatment-retention-in-patients-with-opioid-use-disorder-and-co-morbid-depression-manza-et-al-2025/ - Published: 2025-08-23T12:52:12.000Z - Updated: 2025-08-23T12:52:12.000Z - Description: Ketamine was safe and generally well-tolerated. At 10-day follow-up post-ketamine infusions, participant acceptability ratings were mostly favorable. 3-month timepoint - strong treatment adherence with self-reported depression symptoms decrease - Author: Michael DeMarco, PhD - Tags: opioid use disorder, ketamine therapy, ketamine, iv ketamine, addiction, recovery, methadone [Ketamine to enhance methadone treatment retention in patients with opioid use disorder and co-morbid depression - PubMedBackground: Opioid use disorder (OUD) is a chronic relapsing condition with a high mortality rate. While medications such as methadone are valuable first-line therapies, retention is poor, with the highest dropout rates early in a treatment attempt. Poor outcomes are due in part to the very h …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-48.png)PubMedPeter Manza![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-47.jpg)](https://pubmed.ncbi.nlm.nih.gov/40844815/) "Randomized controlled trials are warranted to test whether ketamine may be a feasible and safe adjunctive treatment for OUD in patients initiating methadone treatment." (2025)