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# Spotlight: Efficacy and safety of ketamine maintenance therapy in treatment-resistant depression: A systematic review of treatment protocols and clinical outcomes (Al-Garni, et al, 2025)
- URL: https://psychedelicmentalhealth.net/spotlight-efficacy-and-safety-of-ketamine-maintenance-therapy-in-treatment-resistant-depression-a-systematic-review-of-treatment-protocols-and-clinical-outcomes-al-garni-et-al-2025/
- Published: 2025-10-19T10:57:04.000Z
- Updated: 2025-10-19T10:57:04.000Z
- Description: "Concurrent psychotherapy improved treatment maintenance. Adverse events were generally mild to moderate... Ketamine maintenance therapy shows promise as a treatment option for TRD, with regular dosing schedules and early intervention associated with optimal outcomes."
- Author: Michael DeMarco, PhD
- Tags: ketamine, ketamine therapy, ketamie research, ketamine assisted psychotherapy, ketamine assisted therapy, psychedelic research, psychedelic assisted psychotherapy, ketamine depression, ketamine safety, ketamine efficacy, ketamine maintenance, ketamine for depression

[Efficacy and safety of ketamine maintenance therapy in treatment-resistant depression: A systematic review of treatment protocols and clinical outcomes - PubMedKetamine maintenance therapy shows promise as a treatment option for TRD, with regular dosing schedules and early intervention associated with optimal outcomes. While safety profiles are reassuring, standardized protocols and careful patient selection remain essential. Future research should focus o …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-127.png)PubMedAbdulaziz M Al-Garni![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-126.jpg)](https://pubmed.ncbi.nlm.nih.gov/41109417/)