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# Spotlight: Real-world clinical data on the long-term effectiveness and safety of generic racemic ketamine treatment (Massaneda-Tuneu, et al, 2025)
- URL: https://psychedelicmentalhealth.net/real-world-clinical-data-on-the-long-term-effectiveness-and-safety-of-generic-racemic-ketamine-treatment-massaneda-tuneu-et-al-2025-2/
- Published: 2025-10-10T23:39:05.000Z
- Updated: 2025-10-11T01:52:55.000Z
- Description: "Findings suggested that racemic ketamine (including by mouth), when appropriately dosed and administered within a structured clinical and safety monitoring framework, is both effective, safe and well-tolerated over a 6-month treatment period."
- Author: Michael DeMarco, PhD
- Tags: at home ketamine, at home ketamine therapy, ketamine therapy, ketamine by mouth, oral ketamine, racemic ketamine, ketamine for depression, suicidality ketamine, depression treatment, treatment resistant depression, ketamine safety, ketamine study, ketamine research, ketamine harm reduction, ketamine addiction, ketamine-assisted psychotherapy, ketamine-assisted therapy, ketamine psychedelic therapy, psychedelic research, psychedelic-assisted psychotherapy, psychedelic ketamine therapy, ketamine tolerability study, ketamine P.O.

[![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/2025/10/image-5.png)](https://www.sciencedirect.com/science/article/pii/S0165032725016349)

(2025): "Data suggested effectiveness, with response rates of 35 % at 8 weeks (16/45) and 44.2 % at 6 months (19/43). Suicidality scores improved in 73.3 % of patients at their last available assessment. Similarly, the results indicated that racemic ketamine was well tolerated. Our findings suggest structured safety monitoring facilitated early identification of emerging adverse effects in a few patients, allowing prompt clinical management, with no adverse sequelae.These findings support the effectiveness and safety of long-term racemic ketamine treatment for patients with TRD and highlight the importance of using a structured safety monitoring framework in clinical care."

[Low-cost ketamine treatment for depression found to be effective long termA new study shows longer-term use of generic ketamine for severe depression is safe and effective, but researchers say access to the low-cost option remains limited by funding gaps.![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/apple-touch-icon-180x180-4.png)UNSW SitesColleen Loo![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/GettyImages-1441480865.cropimg.width-700.crop-landscape-2.jpg)](https://www.unsw.edu.au/newsroom/news/2025/10/low-cost-ketamine-treatment-for-depression-found-to-be-effective-long-term)