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# Spotlight: The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal (Lehane, et al, 2025)
- URL: https://psychedelicmentalhealth.net/low-dose-ketamine-and-2r-6r-hydroxynorketamine-on-affective-behaviors-associated-with-protracted-oxycodone-withdrawal/
- Published: 2025-10-05T11:43:30.000Z
- Updated: 2025-10-05T11:43:30.000Z
- Description: "These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal. "
- Author: Michael DeMarco, PhD
- Tags: oxycodone withdrawal, addiction, recovery, ketamine, ketamine research, ketamine in recovery, psychedelics in recovery, substance use disorder, addiction research

[The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal - PubMedThese findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal.![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-120.png)PubMedMichael J Lehane![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-119.jpg)](https://pubmed.ncbi.nlm.nih.gov/41045335/)

(2025) "These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal."