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# Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model (Dong, et al, 2025)
- URL: https://psychedelicmentalhealth.net/ketamine-sustains-and-enhances-the-protective-effects-of-a-ketogenic-diet-against-relapses-in-an-anorexia-mouse-model-dong-et-al-2025/
- Published: 2025-10-08T11:12:30.000Z
- Updated: 2025-10-08T11:12:30.000Z
- Description: "Ketamine sustains and boosts Ketogenic Diet benefits for > 10 days, supporting clinical findings that short-term KGD + KET may be an effective treatment for preventing anorexia nervosa relapses."
- Author: Michael DeMarco, PhD
- Tags: ketamine, keto, ketogenic diet, anorexia, eating disorders, ketamine treatment, ketamine therapy, ketamine research, anorexia nervosa

[Ketamine Sustains and Enhances the Protective Effects of a Ketogenic Diet Against Relapses in an Anorexia Mouse Model - PubMedAnorexia nervosa (AN) has high mortality and relapse rates, yet no accepted pharmacotherapies. Reports based on six individuals suggest that ketogenic diet (KGD) combined with sub-anesthetic ketamine (KET) is an effective treatment. The animal model, Activity-Based Anorexia (ABA), captures AN’s mala …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-122.png)PubMedYiru Dong![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-121.jpg)](https://pubmed.ncbi.nlm.nih.gov/41058239/)

(2025): "EM revealed that KGD increases GABAergic synapse lengths and may reduce ABA vulnerability by increasing excitatory synaptic drive of GABAergic interneurons and increasing E-to-E synapses' role in body weight regulation."