Ketamine Research
Ketamine Therapy Research:
Selected Bibliography spanning 60 years of research | Bibliogpraphy updated weekly | Institute Approach adjusted accordingly
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PharmaTher Announces FDA Approval of Ketamine (KETARx™)
TORONTO, ON – August 11, 2025 – PharmaTher Holdings Ltd. (the “Company” or “PharmaTher”) (OTCQB: PHRRF) (CSE: PHRM), a specialty pharmaceutical company focused on unlocking the…
Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression (Anand, et al 2023)
Predicting Antidepressant Effects of Ketamine: the Role of the Pregenual Anterior Cingulate Cortex as a Multimodal Neuroimaging Biomarker (Weigand, et al, 2022)
Exploring Ketamine’s Antimicrobial Effects & Fungal Sources: Part 1 (Teske, 2022)
Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability (Apeldoorn, et al, 2022)
Depression and antidepressant effects of ketamine and its metabolites: The pivotal role of gut microbiota (Hua, 2022)
Ketamine and its metabolites: Potential as novel treatments for depression (Zhang, 2022)
The effect of IV ketamine in patients with major depressive disorder and elevated features of borderline personality disorder (Chen, et al, 2022)
Gender differences in the antianhedonic effects of repeated ketamine infusions in patients with depression (Zheng, 2022)
An Expert-Informed
Introduction to the Elements
of Psychedelic-Assisted Therapy (Brainfutures, 2022)Ketamine may exert rapid antidepressant effects through modulation of neuroplasticity, autophagy, and ferroptosis in the habenular nucleus (Zhang, et al, 2022)
Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With Treatment-Resistant Depression (BottemanN, et al, 2022)
Safety, effectiveness and tolerability of sublingual ketamine in depression and anxiety: A retrospective study of off-label, at-home use (Hassan, et al, 2022)
Real-world depression, anxiety and safety outcomes of intramuscular ketamine treatment: a retrospective descriptive cohort study (Ahuja, et al, 2022)
Towards an understanding of psychedelic-induced neuroplasticity (Calder & Hasler, 2022)
Neurobiological, behavioral, and cognitive effects of ketamine in adolescents: A review of human and pre-clinical research (Acevedo, et al, 2022)
Ketamine for suicidality: An umbrella review (Shamabadhi, et al, 2022)
Ketamine induces rapid antidepressant effects via the autophagy-NLRP3 inflammasome pathway (Lyu, et al, 2022)
Active mechanisms of ketamine-assisted psychotherapy: A systematic review (Joneborg, 2022)
Psychedelic integration: An analysis of the concept and its practice (Bathje, et al, 2022)
Comparison of psychedelic and near-death or other non-ordinary experiences in changing attitudes about death and dying (Sweeney, et al, 2022)
Clinical Effectiveness of Intravenous Racemic Ketamine Infusions in a Large Community Sample of Patients With Treatment-Resistant Depression, Suicidal Ideation, and Generalized Anxiety Symptoms: A Retrospective Chart Review (Oliver, et al, 2022)
Magnetoencephalography biomarkers of suicide attempt history and antidepressant response to ketamine in treatment-resistant major depression (Gilbert, 2022)
Ketamine Augmented Psychotherapy (KAP) in mood disorder: User guide (Bottemanne et al, 2022)
Low addiction risk with medical use of ketamine: Animal study (2022)
A short burst of reward curbs the addictiveness of ketamine (2022)
The abuse liability of ketamine: A scoping review of preclinical and clinical studies (Le, et al, 2022)
Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature (Drozdz et al, 2022)
At-home, sublingual ketamine telehealth is a safe and effective treatment for moderate to severe anxiety and depression: Findings from a large, prospective, open-label effectiveness trial (Hull, et al, 2022)
Ketamine Toxicity (Orhurhu, et al, 2022)
Ketamine for Bipolar Depression: Biochemical, Psychotherapeutic, and Psychedelic Approaches (Bennett et al, 2022)
Psychedelic assisted therapy for major depressive disorder: Recent work and clinical directions (McCartney, et al, 2022)
Sustained effects of single doses of classical psychedelics in humans (2022)
A Systematic Review of Neurocognitive Effects of Subanesthetic Doses of Intravenous Ketamine in Major Depressive Disorder, Post-Traumatic Stress Disorder, and Healthy Population (Shiroma, et al 2022)
Ethnoracial Inclusion in Clinical Trials of Ketamine in the Treatment of Mental Health Disorders (Michaels, et al, 2022)
A case series of group-based ketamine-assisted psychotherapy for patients in residential treatment for eating disorders with comorbid depression and anxiety disorders (Robison & LaFrance, 2022)
Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial (2022)
The effect of ketamine on anhedonia: improvements in dimensions of anticipatory, consummatory, and motivation-related reward deficits (2022)
Real-world effectiveness of ketamine in treatment-resistant depression: A systematic review & meta-analysis (Alnefeesi, et al, 2022)
Psychedelics, Mystical Experience, and Therapeutic Efficacy: A Systematic Review (2022)
Buddhist-like opposite diminishing and non-judging during ketamine infusion are associated with antidepressant response: an open-label personalized-dosing study (Stocker et al, 2022)
Psychedelics and Psychotherapy: Cognitive-Behavioral Approaches as Default (2022)
Toward Synergies of Ketamine and Psychotherapy (2022)
Long-term safety of ketamine and esketamine in treatment of depression (2022)
Oral ketamine reduces the experience of stress in people with chronic suicidality (Dutton, et al, 2022)
Ketamine Modulates the Neural Correlates of Reward Processing in Unmedicated Patients in Remission From Depression (2022)
Neurocognitive effects of repeated ketamine infusion treatments in patients with treatment resistant depression: a retrospective chart review (2022)
Analysis of recreational psychedelic substance use experiences classified by substance (Hase, A., Erdmann, M., Limbach, V. et al, 2022)
Brain Changes Associated With Long-Term Ketamine Abuse, A Systematic Review (Strous, et al 2022)
A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers With PTSD and Depression (2022)
A Retrospective Naturalistic Study Comparing the Efficacy of Ketamine and Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression (2022)
A retrospective analysis of ketamine intravenous therapy for depression in real-world care settings (2022)
Adjunctive Ketamine With Relapse Prevention-Based Psychological Therapy in the Treatment of Alcohol Use Disorder (Grabski, et al, 2022)
Mechanisms of ketamine and its metabolites as antidepressants (Hess,et al, 2022)
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review (Walsh, et al, 2022)
Anterior default mode network and posterior insular connectivity is predictive of depressive symptom reduction following serial ketamine infusion (Wade, et al, 2022)
Frontoparietal and Default Mode Network Contributions to Self-Referential Processing in Social Anxiety Disorder (Dixon, 2021)
Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression (Wang, et al, 2021)
Low dose oral ketamine treatment in chronic suicidality: An open-label pilot study (Can, et al, 2021)
Ketamine Treatment for Depression in Patients With a History of Psychosis or Current Psychotic Symptoms: A Systematic Review (Veraart, et al, 2021)
The effectiveness, safety and tolerability of ketamine for depression in adolescents and older adults: A systematic review (Di Vincinzo, et al, 2021)
Six-week oral ketamine treatment for chronic suicidality is associated with increased grey matter volume (Gallay, 2021)
Ketamine-Assisted Psychotherapy for PTSD Related to Racial Discrimination (Halstead, et al, 2021)
Ketamine-assisted psychotherapy for trauma-exposed patients in an outpatient setting: A clinical chart review study (Davis, et al, 2021)
Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial (Wilkinson et aL, 2021)
A Potential Case of Acute Ketamine Withdrawal: Clinical Implications for the Treatment of Refractory Depression (Roxas, et al 2021)
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics (2021)
Ancient Roots of Today's Emerging Renaissance in Psychedelic Medicine (2021)
Can Ketamine be taken orally? (2021)
Efficacy and safety of racemic ketamine and esketamine for depression: a systematic review and meta-analysis (2021)
An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression (2021)
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review (2021)
Novel Insights Into the Neurobiology of the Antidepressant Response From Ketamine Research: A Mini Review (2021)
Ketamine’s Role in Spirituality: How One Synthetic Drug Catalyzes a Natural Experience (Woods, 2021)
Cognitive Behavioral Therapy, Ketamine, and Combination Treatment for Depression: Impressions of Credibility in Participants with Self-Reported Depressive Symptoms (2021)
Ketamine specifically reduces cognitive symptoms in depressed patients: An investigation of associated neural activation patterns (Stippl et al, 2021)
A Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder (2021)
Long-term safety and efficacy of sublingual ketamine troches/lozenges in chronic non-malignant pain management (Maudlin et al, 2021)
Predicting Reactions to Psychedelic Drugs: A Systematic Review of States and Traits Related to Acute Drug Effects (Adal, et al, 2021)
Same But Different: Antidepressant Mechanisms of Psilocybin and Ketamine (Gallenstein, 2021)
Intranasal Ketamine for Depression in Adults: A Systematic Review and Meta-Analysis of Randomized, Double-Blind, Placebo-Controlled Trials (An, et al, 2021)
Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants (Kadriu, et al, 2021)
Pharmacokinetics of ketamine and its major metabolites norketamine, hydroxynorketamine, and dehydronorketamine: a model-based analysis (Kamp, et al, 2020)
GABA interneurons are the cellular trigger for ketamine's rapid antidepressant actions (Gerhard, et al, 2020)
Efficacy of single and repeated administration of ketamine in unipolar and bipolar depression: a meta-analysis of randomized clinical trials (Kryst et al, 2020)
Integrating psychotherapy and psychopharmacology: psychedelic-assisted psychotherapy and other combined treatments (2020)
Characteristic patterns of EEG oscillations in sheep (Ovis aries) induced by ketamine may explain the psychotropic effects seen in humans (2020)
An Update on the Efficacy and Tolerability of Oral Ketamine for Major Depression: A Systematic Review and Meta-Analysis (Nuñez et al, 2020)
Effects of Serial Ketamine Infusions on Corticolimbic Functional Connectivity in Major Depression (Vasavada, et al, 2020)
Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects (Li, et al, 2020)
Ketamine effects on default mode network activity and vigilance: A randomized, placebo-controlled crossover simultaneous fMRI/EEG study (Zacharias, et al, 2020)
Oral Ketamine for Depression, 2: Practical Considerations (2019)
Efficacy of ketamine therapy in the treatment of depression (Mandal, et al, 2019)
Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports (Martial, 2019)
The Impact of Childhood Maltreatment on Intravenous Ketamine Outcomes for Adult Patients with Treatment-Resistant Depression (2019)
The Efficacy of Ketamine in the Palliative Care Setting: A Comprehensive Review of the Literature (2019)
Oral Ketamine for Depression: A Systematic Review (Rosenblat et al, 2019)
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites (Yang, 2019)
The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects (Abdallah, et al, 2018)
Ketamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy (Dore, et al, 2018)
A sub-set of psychoactive effects may be critical to the behavioral impact of ketamine on cocaine use disorder: Results from a randomized, controlled laboratory study (Dakwar, 2018)
Ketamine for Depression (Hyde, 2018)
Does oral administration of ketamine accelerate response to treatment in major depressive disorder? Results of a double-blind controlled trial (Arabzadeh 2018)
Repeated oral ketamine for out-patient treatment of resistant depression: randomised, double-blind, placebo-controlled, proof-of-concept study (2018)
Impact of oral ketamine augmentation on hospital admissions in treatment-resistant depression and PTSD: a retrospective study (Hartberg, et al, 2018)
Psychedelics and reconsolidation of traumatic and appetitive maladaptive memories: focus on cannabinoids and ketamine (Fattore, et al, 2018)
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms (Zanos, et al, 2018)
Side-effects associated with ketamine use in depression: a systematic review (Short et al, 2017)
Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency? (2017)
Cognitive behavior therapy may sustain antidepressant effects of intravenous ketamine in treatment-resistant depression (2017)
Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder (2017)
Antidepressant drug action--From rapid changes on network function to network rewiring (2016)
Ketamine: 50 Years of Modulating the Mind (2016)
Ketamine safety and tolerability in clinical trials for treatment-resistant depression (Wan, et al, 2015)
A Rare Urachal Cyst in a Case of Ketamine-induced Cystitis Provides Mechanistic Insights (2015)
Ameliorating treatment-refractory depression with intranasal ketamine: potential NMDA receptor actions in the pain circuitry representing mental anguish (Opler, et al, 2015)
Ketamine Psychedelic Psychotherapy: Focus on its Pharmacology, Phenomenology, and Clinical Applications (Kolp 2014)
What is hydroxynorketamine and what can it bring to neurotherapeutics? (Singh,et al, 2014)
A randomized controlled trial of intranasal ketamine in major depressive disorder (Lapidus, 2014)
Ketamine: Use in Anesthesia (Marland, et al, 2013)
Ketamine Psychedelic Therapy (KPT): A Review of the Results of Ten Years of Research (Kolp 2011)
What did STAR*D teach us? Results from a large-scale, practical, clinical trial for patients with depression (Gaynes, et Al, 2009)
Ketamine-Enhanced Psychotherapy: Preliminary Clinical Observations on its Effects in Treating Death Anxiety Observations on its Effects in Treating Death Anxiety (Kolp, 2007)
Development of a rational scale to assess the harm of drugs of potential misuse (Nutt & King, 2007)
Ketamine psychedelic therapy (KPT): a review of the results of ten years of research (Krupitsky 1997)
Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children (Malinovsky, et al, 1996)
Ketamine Psychotherapy: Results and Mechanisms (Krupitsky 1996)
Evaluation of ketamine HCl for anti-depressant activity (Sofia, 1975)
The Use of Ketamine in Psychiatry (Khorramzadeh, et al, 1973)
CLINICAL TRIAL OF KETAMINE (CI-581): A PRELIMINARY REPORT (Oduntan, et al,1970)