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# Spotlight: Synaptic priming: A framework for pharmacotherapy in depression (Brown, et al, 2025)
- URL: https://psychedelicmentalhealth.net/ketamine-psilocybin-synaptic-priming-a-framework-for-pharmacotherapy-in-depression-brown-et-al-2025/
- Published: 2025-10-10T23:23:28.000Z
- Updated: 2025-10-10T23:23:28.000Z
- Description: "we describe how the indirect relationship between ketamine's pharmacokinetics and sustained antidepressant pharmacodynamics reveals a dosing model (primer pharmacology) that can be harnessed to fine-tune therapeutic outcomes."
- Author: Michael DeMarco, PhD
- Tags: ketamine, psilocybin, ketamine for depression, ketamine therapy, ketamine research, psychedelic research, mechanisms of action, depression treatment

[Synaptic priming: A framework for pharmacotherapy in depression - PubMedRecent antidepressant drug development focuses on a next generation of drugs to rapidly relieve symptoms. Yet, how ketamine, the prototype rapid-acting antidepressant, maintains symptom relief days after drug elimination, and how repeated doses sustain longer-lasting therapeutic effects, remains unc …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-123.png)PubMedKyle A Brown![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-122.jpg)](https://pubmed.ncbi.nlm.nih.gov/41067229/)

(2025)