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# Ketamine/esketamine in the treatment of depression with comorbid borderline personality disorder or traits: A systematic review of effectiveness (Scott, et al, 2025)
- URL: https://psychedelicmentalhealth.net/ketamine-esketamine-in-the-treatment-of-depression-with-comorbid-borderline-personality-disorder-or-traits-a-systematic-review-of-effectiveness-scott-et-al-2025/
- Published: 2025-09-20T17:15:29.000Z
- Updated: 2025-09-20T17:15:29.000Z
- Description: "patients with depression and comorbid borderline personality disorder/traits were equally likely to respond to ketamine/esketamine as those with depression but without borderline personality disorder/traits."
- Author: Michael DeMarco, PhD
- Tags: ketamine, depression, borderline personality disorder, depression treatment, ketamine therapy, ketamine research, research, psychedelic research

[Ketamine/esketamine in the treatment of depression with comorbid borderline personality disorder or traits: A systematic review of effectiveness - PubMedThis is the first systematic review to assess the effectiveness of ketamine/esketamine in this cohort. Our findings suggest that ketamine/esketamine may be useful in improving symptoms of depression, in those with comorbid borderline personality disorder. Limited study data are available; however, g …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-108.png)PubMedEmma Scott![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-107.jpg)](https://pubmed.ncbi.nlm.nih.gov/40974230/)