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# Spotlight: First study to compare two ketamine therapies for patients with severe depression
- URL: https://psychedelicmentalhealth.net/iv-ketamine-therapy-more-effective-than-spravato-esketamine-severe-depression/
- Published: 2025-09-26T15:21:50.000Z
- Updated: 2025-09-26T15:21:50.000Z
- Description: IV ketamine found to offer faster response with greater improvements than FDA-approved intranasal esketamine (Spravato)
- Author: Michael DeMarco, PhD
- Tags: iv ketamine, ketamine therapy, esketamine, spravato, ketamine research, ketamine-assisted-therapy, ketamine depression, iv ketamine for depression, psychedelic research, depression treatment, ketamine for depression, depression

[First study to compare ketamine therapies for patients with severe depression — Harvard GazetteIV ketamine found to offer faster response with greater improvements.![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/cropped-favicon.png)Harvard GazetteMass General Brigham Communications![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/Ketamine.jpg)](https://news.harvard.edu/gazette/story/2025/09/first-study-to-compare-two-ketamine-therapies-for-patients-with-severe-depression/)