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# Spotlight: Efficacy of Intravenous Racemic Ketamine on Global Severity and Individual Symptoms of Depression: An Exploratory Retrospective Analysis (Landrum, et al, 2025)
- URL: https://psychedelicmentalhealth.net/efficacy-of-intravenous-racemic-ketamine-on-global-severity-and-individual-symptoms-of-depression-an-exploratory-retrospective-analysis-landrum-et-al-2025/
- Published: 2025-09-30T19:30:50.000Z
- Updated: 2025-09-30T19:30:50.000Z
- Description: " Maintenance intravenous racemic ketamine therapy demonstrated significant, persistent, and broad efficacy for treatment-resistant depression ...Side effect burden was no greater in higher doses as compared with lower. "
- Author: Michael DeMarco, PhD
- Tags: iv ketamine, ketamine, iv ketamine for depression, ketamine research, ketamine therapy, ketamine efficacy, depression treatment, ketamine depression, ketamine assisted therapy, research, psychedelic research

[Efficacy of Intravenous Racemic Ketamine on Global Severity and Individual Symptoms of Depression: An Exploratory Retrospective Analysis - PubMedMaintenance intravenous racemic ketamine therapy demonstrated significant, persistent, and broad efficacy for treatment-resistant depression as demonstrated by reductions in Montgomery-Åsberg Depression Rating Scale and Patient-Health Questionnaire-9 total scores and equivocal changes in every item …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-113.png)PubMedRachel E Landrum![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-112.jpg)](https://pubmed.ncbi.nlm.nih.gov/41026463/)

(2025) "The magnitude of change in individual items was similar to that of previous randomized trials, with suicidal ideation and depression demonstrating the largest response and appetite disturbance the least."