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# Spotlight: Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial
- URL: https://psychedelicmentalhealth.net/comparing-the-cognitive-effects-of-repeated-intravenous-ketamine-and-electroconvulsive-therapy-in-patients-with-treatment-resistant-depression/
- Published: 2025-09-03T18:26:34.000Z
- Updated: 2025-09-03T18:26:34.000Z
- Description: "Patients treated with ketamine demonstrated superior cognitive functioning compared with ECT following a 3-week treatment, no differences between treatments observed. Findings support short-term superiority of ketamine on cognitive functioning and the long-term cognitive safety of both treatments."
- Author: Michael DeMarco, PhD
- Tags: ketamine repeated doses, repeated ketamine use, iv ketamine, ketamine research, ect, research, depression, ketamine for depression, ketamine safety, effects

[Comparing the Cognitive Effects of Repeated Intravenous Ketamine and Electroconvulsive Therapy in Patients With Treatment-Resistant Depression: A Secondary Analysis of the ELEKT-D Trial - PubMed<span><b>Objective:</b> Electroconvulsive therapy (ECT) has potent antidepressant effects yet can lead to neurocognitive side effects. Ketamine is a rapid-acting antidepressant, which may be an alternative to ECT. Few have directly compared the cognitive effects of ECT and ketamine treatment. <b>Methods:</b></span> …![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/icon/favicon-192-89.png)PubMedKristina T Kumpf![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/thumbnail/pubmed-meta-image-v2-88.jpg)](https://pubmed.ncbi.nlm.nih.gov/40900112/)

Comparación de los efectos cognitivos de la ketamina intravenosa repetida y la terapia electroconvulsiva en pacientes con depresión resistente en tratamiento: Análisis secundario del ensayo ELEKT-D

***Los pacientes tratados con ketamina demostraron un funcionamiento cognitivo superior en comparación con la TEC después de un tratamiento de 3 semanas, sin diferencias entre los tratamientos observados. Los hallazgos apoyan la superioridad a corto plazo de la ketamina sobre el funcionamiento cognitivo y la seguridad cognitiva a largo plazo de ambos tratamientos.***