> ## Content Index
> Fetch the complete content index at: https://psychedelicmentalhealth.net/llms.txt
> Use this file to discover other available public pages before exploring further.

# Spotlight: Comparative Effects of Repeated Ketamine Infusion Versus Intranasal Esketamine in Patients With Treatment-Resistant Depression: A Retrospective Chart Review (Meisner, et al, 2025)
- URL: https://psychedelicmentalhealth.net/comparative-effects-of-repeated-ketamine-infusion-versus-intranasal-esketamine-in-patients-with-treatment-resistant-depression-a-retrospective-chart-review-meisner-et-al-2025/
- Published: 2025-09-24T13:14:55.000Z
- Updated: 2025-09-24T13:14:55.000Z
- Description: "In this naturalistic sample of patients with similarly severe TRD treated in a ketamine subspecialty service over a 4–5-week induction period, treatment with IV racemic ketamine was associated with a more rapid response and greater overall efficacy than treatment with IN esketamine."
- Author: Michael DeMarco, PhD
- Tags: ketamine, iv ketamine, esketamine, depression treatment, ketamine depression, ketamine therapy, ketamine-assisted therapy, depression, ketamine research, psychedelic research

[![](https://storage.ghost.io/c/61/a8/61a8484e-df24-47fb-903c-d012ff10c983/content/images/2025/09/image-24.png)](https://www.psychiatrist.com/jcp/repeated-ketamine-infusion-vs-intranasal-esketamine-patients-treatment-resistant-depression-chart-review/)

(2025): "In this naturalistic sample of patients with similarly severe TRD treated in a ketamine subspecialty service over a 4–5-week induction period, treatment with IV racemic ketamine was associated with a more rapid response and greater overall efficacy than treatment with IN esketamine."In this naturalistic sample of patients with similarly severe TRD treated in a ketamine subspecialty service over a 4–5-week induction period, ****treatment with IV racemic ketamine was associated with a more rapid response and greater overall efficacy than treatment with IN esketamine.**"